The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.
Open accessAbstract
Thrombopoietin (TPO) has recently been cloned and shown to regulate megakaryocyte and platelet production by activating the cytokine receptor c-mpl. To determine whether TPO is the only ligand for c-mpl and the major regulator of megakaryocytopoiesis, TPO deficient mice were generated by gene targeting. TPO-/- mice have a >80% decrease in their platelets and megakaryocytes but have normal levels of all the other hematopoietic cell types. A gene dosage effect observed in heterozygous mice suggests that the TPO gene is constitutively expressed and that the circulating TPO level is directly regulated by the platelet mass. Bone marrow from TPO-/- mice have decreased numbers of megakaryocyte-committed progenitors as well as lower ploidy in the megakaryocytes that are present. These results demonstrate that TPO alone is the major physiological regulator of both proliferation and differentiation of hematopoietic progenitor cells into mature megakaryocytes but that TPO is not critical to the final step of platelet production.
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Citations
Cites
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B. E., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., et al. (1994) · Nature · doi:10.1038/369533a0 · Cited by 1,263
Self-citationCloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
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Bartley, T. (1994) · Cell · doi:10.1016/0092-8674(94)90450-2 · Cited by 940
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Thrombocytopenia in c-mpl-deficient mice
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Self-citationc-Mpl ligand is a humoral regulator of megakaryocytopoiesis
Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D., & Vainchenker, W. (1994) · Nature · doi:10.1038/369571a0 · Cited by 643
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Cited by
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F. A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., et al. (2001) · Blood · doi:10.1182/blood.v98.9.2720 · Cited by 667
Pathogenesis of immune thrombocytopenia
Audia, S., Mahévas, M., Samson, M., Godeau, B., & Bonnotte, B. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.04.012 · Cited by 395
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
Kimura, S., Roberts, A. W., Metcalf, D., & Alexander, W. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1195 · Cited by 391
Role of c-mpl in Early Hematopoiesis
Solar, G. P., Kerr, W. G., Zeigler, F. C., Hess, D., Donahue, C., de Sauvage, F. J., & Eaton, D. L. (1998) · Blood · doi:10.1182/blood.v92.1.4.413k38_4_10 · Cited by 367
Self-citationHeil, G., Hoelzer, D., Sanz, M. A., Lechner, K., Liu Yin, J. A., Papa, G., Noens, L., Szer, J., Ganser, A., O'Brien, C., et al. (1997) · Blood · doi:10.1182/blood.v90.12.4710 · Cited by 332
Metadata
- Authors
- de Sauvage, F. J., Carver-Moore, K., Luoh, S. M., Ryan, A., Dowd, M., Eaton, D. L., & Moore, M. W.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-02-01
- Volume
- 183
- Issue
- 2
- Pages
- 651-656
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145139769
- Cited by
- 423
- References
- 21
- FWCI
- 26.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. https://app.cochat.ai/papers/10.1084/jem.183.2.651
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- de Sauvage, F. J., Carver-Moore, K., Luoh, S. M., Ryan, A., Dowd, M., Eaton, D. L., & Moore, M. W. (1996). Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.2.651
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
