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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
Open accessAbstract
The Src-family and Syk/ZAP-70 family of protein tyrosine kinases (PTK) are required for T cell receptor (TCR) functions. We provide evidence that the Src-family PTK Lck is responsible for regulating the constitutive tyrosine phosphorylation of the TCR zeta subunit in murine thymocytes. Moreover, ligation of the TCR expressed on thymocytes from Lck-deficient mice largely failed to induce the phosphorylation of TCR-zeta, CD3 epsilon, or ZAP-70. In contrast, we find that the TCR-zeta subunit is weakly constitutively tyrosine phosphorylated in peripheral T cells isolated from Lck-null mice. These data suggest that Lck has a functional role in regulation of TCR signal transduction in thymocytes. In peripheral T cells, other Src-family PTKs such as Fyn may partially compensate for the absence of Lck.
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Cited by
Crowley, M. T., Costello, P. S., Fitzer-Attas, C. J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V. L. J., & DeFranco, A. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1027 · Cited by 506
Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
Stahn, C., Löwenberg, M., Hommes, D. W., & Buttgereit, F. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.019 · Cited by 419
Glucocorticoids Attenuate T Cell Receptor Signaling
Van Laethem, F., Baus, E., Smyth, L. A., Andris, F., Bex, F., Urbain, J., Kioussis, D., & Leo, O. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.803 · Cited by 118
Gabaev, I., Steinbrück, L., Pokoyski, C., Pich, A., Stanton, R. J., Schwinzer, R., Schulz, T. F., Jacobs, R., Messerle, M., & Kay-Fedorov, P. C. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002432 · Cited by 58
Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
Castro-Sanchez, P., Teagle, A. R., Prade, S., & Zamoyska, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.608747 · Cited by 44
Metadata
- Authors
- van Oers, N. S., Killeen, N., & Weiss, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-03-01
- Volume
- 183
- Issue
- 3
- Pages
- 1053-1062
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2151734135
- Cited by
- 332
- References
- 0
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. https://app.cochat.ai/papers/10.1084/jem.183.3.1053
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- van Oers, N. S., Killeen, N., & Weiss, A. (1996). Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.3.1053
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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