The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.
Open accessAbstract
Successive T-precursors isolated from adult mouse thymus were examined for their developmental potential, by transfer to irradiated Ly 5-disparate recipients. The earliest, "low CD4" precursors formed T, B, and dendritic cells (DC), but not myeloid cells, in accordance with earlier studies. Surprisingly, the next downstream CD4-8-3 44+25+ precursor population still formed DC as well as T cells although it no longer formed B or myeloid cells. Further down-stream, the CD4-8 3-44-25+ population formed only T cells. The thymic and splenic DC progeny of the early thymic precursors all expressed high levels of CD8 alpha, in contrast with normal splenic DC and the splenic DC progeny of bone marrow stem cells, which consisted of both CD8 and CD8+ DC. A common precursor of T cells and of a subclass of DC is proposed, with CD8 alpha as a marker of the lymphoid-related DC lineage.
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“Whereas ETP and DN2 cells can generate myeloid cells if removed from the thymus, pro-T cells that have differentiated past the stage of PU.1 expression in the thymus (i.e., from the DN2 stage to the DN3 stage or later) do not make myeloid cells under these conditions”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [51]
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Immunobiology of Dendritic Cells
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Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
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Akbari, O., DeKruyff, R. H., & Umetsu, D. T. (2001) · Nature Immunology · doi:10.1038/90667 · Cited by 1,196
Dendritic cell regulation of TH1-TH2 development
Moser, M., & MURPHY, K. M. M. (2000) · Nature Immunology · doi:10.1038/79734 · Cited by 1,114
Metadata
- Authors
- Wu, L., Li, C. L., & Shortman, K.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- ORCID
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-09-01
- Volume
- 184
- Issue
- 3
- Pages
- 903-911
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2192802
- OpenAlex
- W2149939821
- Cited by
- 400
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 8
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- thymic dendritic cells, dendritic cell precursors, common lymphoid progenitors, B cell development, myeloid cell development, thymus, splenic dendritic cells, hematopoietic stem cells
- MeSH terms
- Animals, Antigens, Ly, Dendrites, Mice, Inbred C57BL, Phenotype, T-Lymphocytes, Thymus Gland, Mice
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