The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients.
Open accessAbstract
We have demonstrated spontaneous nitric oxide (NO) production by primary synovial cultures from rheumatoid (RA) and osteoarthritis patients. Increased NO production followed addition of staphylococcal enterotoxin B. Immunochemical double staining with specific anti-human inducible NO synthase (iNOS) and nonspecific esterase (NSE), or anti-CD68 (markers for tissue macrophages) showed that although many lining layer cells in RA synovium expressed iNOS, most (approximately 90%) were NSE- and CD68-, with only a minor population (approximately 10%) which were iNOS+, CD68+/NSE+. These data demonstrate the capacity for high output of NO by human synovial tissue and show that, although human macrophages can express high levels of iNOS, the majority of cells expressing iNOS are fibroblasts. We also report that synoviocytes, and macrophage cell lines, cultured with the NO donor, S-nitroso-acetyl penicillamine, produced high concentrations of tumor necrosis factor (TNF)-alpha. These results suggest that NO may mediate pathology in RA through the induction of TNF-alpha production.
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The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,514
The Staphylococcal Enterotoxins and Their Relatives
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Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Regulation of biosynthesis of nitric oxide.
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Suppression of arthritis by an inhibitor of nitric oxide synthase.
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Nitric oxide and asthmatic inflammation
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
Robinson, W. H., Lepus, C. M., Wang, Q., Raghu, H., Mao, R., Lindstrom, T. M., & Sokolove, J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.136 · Cited by 1,438
ROS/oxidative stress signaling in osteoarthritis
Lepetsos, P., & Papavassiliou, A. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.003 · Cited by 801
Inducible nitric oxide synthase in human diseases
Kröncke, K.-D., Fehsel, K., & Kolb-Bachofen, V (2001) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.1998.00648.x · Cited by 585
Van'T Hof, R. J., & Ralston, S. H. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01261.x · Cited by 518
Metadata
- Authors
- McInnes, I. B., Leung, B. P., Field, M., Wei, X. Q., Huang, F. P., Sturrock, R. D., Kinninmonth, A., Weidner, J., Mumford, R., & Liew, F. Y.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-10-01
- Volume
- 184
- Issue
- 4
- Pages
- 1519-1524
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2119108876
- Cited by
- 288
- References
- 27
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- green
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- McInnes, I. B., Leung, B. P., Field, M., Wei, X. Q., Huang, F. P., Sturrock, R. D., Kinninmonth, A., Weidner, J., Mumford, R., & Liew, F. Y. (1996). Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. The Journal of experimental medicine. https://doi.org/10.1084/jem.184.4.1519
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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