The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin
Open accessAbstract
Microglial cells express a peculiar plasma membrane receptor for extracellular ATP, named P2Z/P2X7 purinergic receptor, that triggers massive transmembrane ion fluxes and a reversible permeabilization of the plasma membrane to hydrophylic molecules of up to 900 dalton molecule weight and eventual cell death (Di Virgilio, F. 1995. Immunol. Today. 16:524–528). The physiological role of this newly cloned (Surprenant, A., F. Rassendren, E. Kawashima, R.A. North and G. Buell. 1996. Science (Wash. DC). 272:735–737) cytolytic receptor is unknown. In vitro and in vivo activation of the macrophage and microglial cell P2Z/P2X7 receptor by exogenous ATP causes a large and rapid release of mature IL-1β. In the present report we investigated the role of microglial P2Z/P2X7 receptor in IL-1β release triggered by LPS. Our data suggest that LPS-dependent IL-1β release involves activation of this purinergic receptor as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP-hydrolyzing enzymes such as apyrase or hexokinase. Furthermore, microglial cells release ATP when stimulated with LPS. LPS-dependent release of ATP is also observed in monocyte-derived human macrophages. It is suggested that bacterial endotoxin activates an autocrine/paracrine loop that drives ATP-dependent IL-1β secretion.
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Cites
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,572
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
Dinarello, C. A. (1984) · Clinical Infectious Diseases · doi:10.1093/clinids/6.1.51 · Cited by 1,644
ENDOTOXINS AND DISEASE MECHANISMS
Morrison, D. C., & Ryan, J. L. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.002221 · Cited by 1,103
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.
Rubartelli, A., Cozzolino, F., Talio, M., & Sitia, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08268.x · Cited by 781
Perregaux, D., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 758
Signalling via ATP in the nervous system
Zimmermann, H. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90016-7 · Cited by 437
The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death
Di Virgilio, F. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80045-x · Cited by 372
Self-citationOxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.
Murgia, M., Hanau, S., Pizzo, P., Rippa, M., & Di Virgilio, F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53082-9 · Cited by 367
Self-citationMouse microglial cells express a plasma membrane pore gated by extracellular ATP
Ferrari, D., Villalba, M., Chiozzi, P., Falzoni, S., Ricciardi-Castagnoli, P., & Di Virgilio, F. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1531 · Cited by 352
Self-citation
Cited by
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898
Microglia as a source and target of cytokines
Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645
Cytokines and acute neurodegeneration
Allan, S. M., & Rothwell, N. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094583 · Cited by 1,123
Metadata
- Authors
- Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., & Di Virgilio, F.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-02-03
- Volume
- 185
- Issue
- 3
- Pages
- 579-582
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2164116575
- Cited by
- 474
- References
- 20
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., & Di Virgilio, F. (1997). Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.185.3.579
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