The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Immune Pathogenesis of Hepatocellular Carcinoma
Open accessAbstract
Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV) infection. The pathogenetic mechanisms potentially responsible for HCC during chronic HBV infection are not well defined. This study demonstrates that chronic immune-mediated liver cell injury triggers the development of HCC in the absence of viral transactivation, insertional mutagenesis, and genotoxic chemicals. These results strongly suggest that the immune response to HBV is both necessary and sufficient to cause liver cancer during chronic HBV infection, and that all other procarcinogenic events associated with HCC are probably dependent on this process.
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Cites
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,566
Viral Hepatitis and Liver Disease
Vyas, G. N., Dienstag, J. L., & Hoofnagle, J. H. (1985) · Medical Entomology and Zoology · Cited by 1,860
Hepatitis B Virus Immunopathogenesis
Chisari, F. V. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.29 · Cited by 1,609
Self-citationRisk Factors for Hepatocellular Carcinoma among Patients with Chronic Liver Disease
Tsukuma, H., Hiyama, T., Tanaka, S., Nakao, M., Yabuuchi, T., Kitamura, T., Nakanishi, K., Fujimoto, I., Inoue, A., Yamazaki, H., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306243282501 · Cited by 1,126
Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes
Guidotti, L. G., Ishikawa, T., Hobbs, M. V., Matzke, B., Schreiber, R., & Chisari, F. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80295-2 · Cited by 1,083
Self-citationSurvival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis
Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J., & Strohmeyer, G. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511143132004 · Cited by 1,069
Hepatocellular Carcinoma in Italian Patients with Cirrhosis
Colombo, M., de Franchis, R., Del Ninno, E., Sangiovanni, A., De Fazio, C., Tommasini, M., Donato, M. F., Piva, A., Di Carlo, V., & Dioguardi, N. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109053251002 · Cited by 813
The Incidence of Adenocarcinoma in Columnar-Lined (Barrett's) Esophagus
Cameron, A. J., Ott, B. J., & Payne, W. S. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131404 · Cited by 715
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
Chisari, F. V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H. A., Sell, S., Pinkert, C. A., Brinster, R. L., & Palmiter, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90770-8 · Cited by 697
Self-citationWang, X. W., Forrester, K., Yeh, H., Feitelson, M. A., Gu, J. R., & Harris, C. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2230 · Cited by 665
Cited by
Inflammation as a Tumor Promoter in Cancer Induction
Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature · doi:10.1038/nature24302 · Cited by 589
Immunobiology and pathogenesis of hepatitis B virus infection
Iannacone, M., & Guidotti, L. G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00549-4 · Cited by 520
Self-citationPathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
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Metadata
- Authors
- Nakamoto, Y., Guidotti, L. G., Kuhlen, C. V., Fowler, P., & Chisari, F. V.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-07-20
- Volume
- 188
- Issue
- 2
- Pages
- 341-350
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2062868961
- Cited by
- 373
- References
- 42
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nakamoto, Y., Guidotti, L. G., Kuhlen, C. V., Fowler, P., & Chisari, F. V. (1998). Immune Pathogenesis of Hepatocellular Carcinoma. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.2.341
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
