The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth
Open accessAbstract
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.
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Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Tumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
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RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P., & Cerutti, A. (2002) · Nature Immunology · doi:10.1038/ni829 · Cited by 1,252
RetractedMoreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Rème, T., Lugagne, C., Moine, P., Rossi, J.-F., Klein, B., & Tarte, K. (2004) · Blood · doi:10.1182/blood-2003-06-1984 · Cited by 558
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival
Novak, A. J., Darce, J. R., Arendt, B. K., Harder, B., Henderson, K., Kindsvogel, W., Gross, J. A., Greipp, P. R., & Jelinek, D. F. (2004) · Blood · doi:10.1182/blood-2003-06-2043 · Cited by 554
Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W., French, D. M., Grewal, I. S., Cochran, A. G., Gordon, N. C., Yin, J., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00425-9 · Cited by 477
Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More
Marsden, V. S., & Strasser, A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141029 · Cited by 384
Metadata
- Authors
- Hahne, M., Kataoka, T., Schröter, M., Hofmann, K., Irmler, M., Bodmer, J.-L., Schneider, P., Bornand, T., Holler, N., French, L. E., Sordat, B., Rimoldi, D., & Tschopp, J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-09-21
- Volume
- 188
- Issue
- 6
- Pages
- 1185-1190
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2115528666
- Cited by
- 506
- References
- 2
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth. https://app.cochat.ai/papers/10.1084/jem.188.6.1185
- The paper
- Hahne, M., Kataoka, T., Schröter, M., Hofmann, K., Irmler, M., Bodmer, J.-L., Schneider, P., Bornand, T., Holler, N., French, L. E., Sordat, B., Rimoldi, D., & Tschopp, J. (1998). APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.6.1185
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
