312-nanometer Ultraviolet B Light (Narrow-Band UVB) Induces Apoptosis of T Cells within Psoriatic Lesions

Ozawa, Maki; Ferenczi, Katalin; Kikuchi, Toyoko; Cardinale, Irma; Austin, Lisa M.; Coven, Todd R.; Burack, Lauren H.; Krueger, James G.

doi:10.1084/jem.189.4.711

312-nanometer Ultraviolet B Light (Narrow-Band UVB) Induces Apoptosis of T Cells within Psoriatic Lesions

Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism of action is unknown. In a bilateral comparison clinical study, daily exposure of psoriatic plaques to broad-band UVB (290–320 nm) or 312-nm UVB depleted T cells from the epidermis and dermis …