Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy
Open accessAbstract
The biological functions of immunoglobulin (Ig)A antibodies depend primarily on their interaction with cell surface receptors. Four IgA receptors are presently characterized. The FcαRI (CD89) expressed by myeloid cells selectively binds IgA1 and IgA2 antibodies, whereas the poly-IgR, Fcα/μR, and asialoglycoprotein receptors bind other ligands in addition to IgA. IgA binding by mesangial cells, epithelial cells, and proliferating lymphocytes is also well documented, but the nature of the IgA receptors on these cells remains elusive. A monoclonal antibody (A24) is described here that specifically blocks IgA binding to epithelial and B lymphocyte cell lines. Both the A24 antibody and IgA1 myelomas bind a cell surface protein that is identified as the transferrin receptor (CD71). The transferrin receptor selectively binds IgA1 antibodies, monomeric better than polymeric forms, and the IgA1 binding is inhibitable by transferrin. Transferrin receptor expression is upregulated on cultured mesangial cells as well as on glomerular mesangial cells in patients with IgA nephropathy. The characterization of transferrin receptor as a novel IgA1 receptor on renal mesangial cells suggests its potential involvement in the pathogenesis of IgA nephropathy.
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The MIGA1 gene is associated with iron deficiency anemia and immunity.
“The MIGA1 gene is associated with iron deficiency anemia and immunity (Moura et al., 2001; Rouault, 2006).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Moura et al., 2001
The Discussion identifies the transferrin receptor (TfR/CD71) as an IgA1 receptor, an immune-related finding. Our copy does not identify this receptor as MIGA1 or address an association between the MIGA1 gene and iron deficiency anemia (searched: MIGA1, iron deficiency anemia, iron uptake). (LLM, conf=0.77)
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- Authors
- Moura, I. C., Centelles, M. N., Arcos-Fajardo, M., Malheiros, D. M., Collawn, J. F., Cooper, M. D., & Monteiro, R. C.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- aInstitut National de la Santé et de la Recherche Médicale (INSERM) U25, Necker Hospital, Paris 75743 Cédex 15, France
- Universidade de São Paulo (BR)
- University of Alabama at Birmingham (US)
- Howard Hughes Medical Institute (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-08-13
- Volume
- 194
- Issue
- 4
- Pages
- 417-426
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2193503
- OpenAlex
- W2154801271
- Cited by
- 293
- References
- 42
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 18 · 2014: 11 · 2013: 15 · 2012: 26
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- transferrin receptor, IgA nephropathy, mesangial cells, IgA binding, transferrin, glomerular mesangium, B cells
- MeSH terms
- Animals, Antibodies, Monoclonal, Fluorescent Antibody Technique, Glomerular Mesangium, Glomerulonephritis, IGA, Humans, Immunohistochemistry, Male, Receptors, Fc, Receptors, Transferrin, Up-Regulation, Rats
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