The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
CD4+CD25+ Immunoregulatory T Cells
Open accessAbstract
CD4+CD25+ immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we show that the few CD4+CD25+ T cells naturally present in the transplant regulate GVHD because their removal from the graft dramatically accelerates this disease. Furthermore, the addition of freshly isolated CD4+CD25+ T cells at time of grafting significantly delays or even prevents GVHD. Ex vivo–expanded CD4+CD25+ regulatory T cells obtained after stimulation by allogeneic recipient-type antigen-presenting cells can also modulate GVHD. Thus, CD4+CD25+ regulatory T cells represent a new therapeutic tool for controlling GVHD in allogeneic HSCT. More generally, these results outline the tremendous potential of regulatory T cells as therapeutics.
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Graft-versus-leukemia reactions after bone marrow transplantation
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Self-citationSakaguchi, S. (2000) · Cell · doi:10.1016/s0092-8674(00)80856-9 · Cited by 1,815
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Cited by
Sakaguchi, S. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,306
Regulatory T cells in transplantation tolerance
Wood, K. J., & Sakaguchi, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri1027 · Cited by 1,317
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
Koreth, J., Matsuoka, K.-I., Kim, H. T., McDonough, S. M., Bindra, B., Alyea, E. P., Armand, P., Cutler, C., Ho, V. T., Treister, N. S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1108188 · Cited by 1,119
Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T., Levine, B. L., June, C. H., Rubinstein, P., et al. (2011) · Blood · doi:10.1182/blood-2010-07-293795 · Cited by 1,045
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Metadata
- Authors
- Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D., & Salomon, B. L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-08-05
- Volume
- 196
- Issue
- 3
- Pages
- 401-406
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145030204
- Cited by
- 687
- References
- 27
- FWCI
- 15.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D., & Salomon, B. L. (2002). CD4+CD25+ Immunoregulatory T Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20020090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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