The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma
Open accessAbstract
We studied the function of antitumor T and natural killer T (NKT) cells from the blood and tumor bed in 23 patients with premalignant gammopathy, nonprogressive myeloma, or progressive multiple myeloma. We show that antitumor killer T cells can be detected in patients with both progressive or nonprogressive myeloma. Vα24+Vβ11+ invariant NKT cells are detectable in the blood and tumor bed of all cohorts. However, freshly isolated NKT cells from both the blood and tumor bed of patients with progressive disease, but not nonprogressive myeloma or premalignant gammopathy, have a marked deficiency of ligand-dependent interferon-γ production. This functional defect can be overcome in vitro using dendritic cells pulsed with the NKT ligand, α-galactosylceramide (α-GalCer). Fresh myeloma cells express CD1d, and can be efficiently killed by autologous NKT cells. We hypothesize that presentation of tumor derived glycolipids by myeloma cells leads to NKT dysfunction in vivo. These data demonstrate that clinical progression in patients with monoclonal gammopathies is associated with an acquired but potentially reversible defect in NKT cell function and support the possibility that these innate lymphocytes play a role in controlling the malignant growth of this incurable B cell tumor in patients.
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Cites
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465
T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.
Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., et al. (2000) · Nature · doi:10.1038/35046102 · Cited by 1,358
Cited by
De Santo, C., Arscott, R., Booth, S., Karydis, I., Jones, M., Asher, R., Salio, M., Middleton, M., & Cerundolo, V. (2010) · Nature Immunology · doi:10.1038/ni.1942 · Cited by 304
Lynch, L., O'Shea, D., Winter, D. C., Geoghegan, J., Doherty, D. G., & O'Farrelly, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939349 · Cited by 257
Jinushi, M., Vanneman, M., Munshi, N. C., Tai, Y.-T., Prabhala, R. H., Ritz, J., Neuberg, D., Anderson, K. C., Carrasco, D. R., & Dranoff, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711293105 · Cited by 256
The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression
García-Ortiz, A., Rodríguez-García, Y., Encinas, J., Maroto-Martín, E., Castellano, E., Teixidó, J., & Martínez-López, J. (2021) · Cancers · doi:10.3390/cancers13020217 · Cited by 238
Paul, S., Chhatar, S., Mishra, A., & Lal, G. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0697-7 · Cited by 150
Metadata
- Authors
- Dhodapkar, M. V., Geller, M. D., Chang, D. H., Shimizu, K., Fujii, S.-I., Dhodapkar, K. M., & Krasovsky, J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-06-09
- Volume
- 197
- Issue
- 12
- Pages
- 1667-1676
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2165107917
- Cited by
- 425
- References
- 2
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Dhodapkar, M. V., Geller, M. D., Chang, D. H., Shimizu, K., Fujii, S.-I., Dhodapkar, K. M., & Krasovsky, J. (2003). A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20021650
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