MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

Zhao, Qun, Wang, Xianxi, Nelin, Leif D., Yao, Yongxue, Matta, Ranyia, Manson, Mary E., Baliga, Reshma S., Meng, Xiaomei +4 more·2006·The Journal of Experimental Medicine

Cited by (370)

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  5. Dual Specificity Phosphatase 1 Regulates Human Inducible Nitric Oxide Synthase Expression by p38 MAP Kinase
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  8. Degalactosylated Whey Protein Suppresses Inflammatory Responses Induced by Lipopolysaccharide in Mice
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  9. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production
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  10. Identification of the ZAK-MKK4-JNK-TGFβ Signaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ
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  12. Methylprednisolone Promotes Mycobacterium smegmatis Survival in Macrophages through NF-κB/DUSP1 Pathway
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  16. Effects of glycogen synthase kinase-3[beta] inhibition on the development of cerulein-induced acute pancreatitis in mice *
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  17. Mitogen-activated protein kinase phosphatase-1 controls PD-L1 expression by regulating type I interferon during systemic Escherichia coli infection
    Timothy J. Barley, Parker R. Murphy, Xiantao Wang, Bridget A. Bowman, Justin M. Mormol, Carli E. Mager, Sean G. Kirk, Charles Joseph Cash, Sarah C. Linn, Xiaomei Meng et al. · 2022 · Journal of Biological Chemistry
  18. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus
    Koichi Adachi, Motomitsu Goto, Takeshi Onoue, Taku Tsunekawa, Miyuki Shibata, Shigeru Hagimoto, Yoshihiro Ito, Ryoichi Banno, Hidetaka Suga, Yoshihisa Sugimura et al. · 2014 · Neuroscience Letters
  19. Experimental Control of Macrophage Pro-Inflammatory Dynamics Using Predictive Models
    Laura D. Weinstock, James E. Forsmo, Alexis Wilkinson, Jun Ueda, Levi Benjamin Wood · 2020 · Frontiers in Bioengineering and Biotechnology
  20. The dataset describes: HIF-1 α expression and LPS mediated cytokine production in MKP-1 deficient bone marrow derived murine macrophages
    Harvinder S. Talwar, Christian P. Bauerfeld, Liu Y, Lobelia Samavati · 2017 · Data in Brief
  21. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection
    Sean G. Kirk, Parker R. Murphy, Xiantao Wang, Charles Joseph Cash, Timothy J. Barley, Bridget A. Bowman, Abel J. Batty, William E. Ackerman, Jian Zhang, Leif Daniel Nelin et al. · 2021 · The Journal of Immunology
  22. Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy
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  23. Host–parasite interactions after in vitro infection of human macrophages by Leishmania major: Dual analysis of microRNA and mRNA profiles reveals regulation of key processes through time kinetics
    Chiraz Atri, Ghada Mkannez, Hanène Attia, R.M. Sghaier, Aymen Bali, Ali Ben-Cheikh, Imen Rabhi, Béatrice Regnault, David Piquemal, Kaïs Ghedira et al. · 2025 · Microbes and Infection
  24. Heat Stress Influences Immunity Through DUSP1 and HSPA5 Mediated Antigen Presentation in Chickens
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  27. Mitogen-activated protein kinase phosphatase-1 and septic shock
    Liu Y, Thomas P. Shanley · 2008 · Journal of Organ Dysfunction
  28. MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
    Laipeng Feng, Huiying Wang, Chen Chen, Jiacheng Fu, Liqin Zhao, Xia Zhao, Mengjun Geng, Mengdi Ren, Lidan Tong, Yan Li et al. · 2024 · Behavioural Brain Research
  29. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses
    Hongbo Chi, Anton M. Bennett, Richard Anthony Flavell · 2006 · Journal of Organ Dysfunction
  30. PDE 4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase‐1 by a mechanism dependent on MAP kinase phosphatase‐1
    Lauri Tuure, Mari Hämäläinen, Eeva Moilanen · 2017 · Pharmacology Research & Perspectives
  31. Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature
    Min Wang, Ting Wan, Yan Luo · 2010 · Springer eBooks
  32. MAP Kinase Phosphatases
    Stephen M. Keyse · 2010 · Elsevier eBooks
  33. Clostridium difficile toxin B-induced colonic inflammation is mediated by the FOXO3/PPM1B pathway in fetal human colon epithelial cells.
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  34. Negative Regulators of the Host Response in Sepsis
    Timothy Thomas Cornell · 2011 · The Open Inflammation Journal
  35. Update in Critical Care 2005
    Eric B Milbrandt, Akitoshi Ishizaka, Derek C. Angus · 2006 · American Journal of Respiratory and Critical Care Medicine
  36. Role of Dual Specificity Phosphatase in Stress and Starch Metabolism
    Kanwaljeet Kaur, Manas Kumar Tripathy, Girdhar Kumar Pandey · 2020 · Springer eBooks
  37. Inmunoterapia genética con células dendríticas para el tratamiento del cáncer
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  38. Erratum: Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA
    Gopinath Krishnan, Nivedita Chatterjee · 2015 · Scientific Reports
  39. The Low Expression of DUSP1 and HSPA5 Inhibits Chicken Immune Response and Causes Decreased Immunity under Heat Stress
    Wenwu Zhang, Jiguo Xu, Hongmei Li, Lianghui Zhou, Qinghua Nie, Xiquan Zhang, Qingbin Luo · 2019
  40. Search for Potential VDR/Partner Composite Elements in Regulatory DNA of Genes Associated with Respiratory Infections and Atopic Diseases
    Alexey V. Popov, Dmitry Y. Oshchepkov, Vladislav V. Kononchuk, Tatiana S. Kalinina, I.S. Valembakhov, Alexander D. Lukin, Elena G. Kondyurina, Vera V. Zelenskaya, Вавилин Валентин Андреевич · 2025 · International Journal of Molecular Sciences
  41. Dendritic cells in cancer immunotherapy
    María Gato, Thérèse Liechtenstein, Idoia Blanco‐Luquin, Isabel Zudaire, Grazyna T. Kochan, David Escors · 2015 · Anales del Sistema Sanitario de Navarra
  42. Glutamine Inhibits TNF-α-induced Cytosolic Phospholipase A2 Activation via Upregulation of MAPK Phosphatase-1
    So Young Yoon, Soo-Yeon Jeong, Suhn‐Young Im · 2021 · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters
  43. MKP1 — a dynamic immune regulator
    Olive Leavy · 2006 · Nature reviews. Immunology
  44. Efficient Immune Cell Genome Engineering with Improved CRISPR Editing Tools
    Waipan Chan, Rachel A. Gottschalk, Yikun Yao, Joel L. Pomerantz, Ronald N. Germain · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae
    Shaunna R. Simmons, Annabel Rivera, Elsa N. Bou Ghanem · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Induction of ABCA1 Expression Is Correlated With Increased CREB Phosphorylation and Altered Cytokine Secretion
    Maryam Zaid · 2011 · uO Research (University of Ottawa)
  47. Role of Rac1 in myocardial TNF-alpha expression in sepsis
    Ting Zhang · 2011 · Scholarship@Western (Western University)
  48. Mitogen-activated Protein Kinase Phosphatases in Inflammation and as Anti-inflammatory Drug Targets
    Tuija Hömmö · 2014 · Tampere University Institutional Repository (Tampere University)
  49. Mecanismos moleculares que regulan la activación clásica y alternativa en los macrófagos
    Luis Toribio · 2008 · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
  50. Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases
    Kelly L. Brown · 2011 · Wiley eBooks
  51. Efecto de la doxorubicina sobre MKP-1 en el cáncer de mama humano y asociación entre la expresión de MKP-1 y la evolución de las pacientes
    Federico Rojo · 2012 · TDX (Tesis Doctorals en Xarxa)
  52. O papel crítico da sinalização TLR/MyD88 no efeito inibitório das proteases Natterinas no recrutamento celular.
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  54. Role of MAPK phosphatase‑1 (MKP‑1) in the induction of MCP‑1 during the course of adipocyte hypertrophy
    Ayaka Ito, Takayoshi Suganami, Yasutomi Kamei, Yoshihiro Ogawa · 2008
  55. Molecular mechanisms of anti-inflammatory glucocorticoid action: Evidence for a role of glucocorticoid-inducible genes and implications for glucocorticoid insensitivity
    Suharsh Shah · 2016 · Libraries and Cultural Resources (University of Calgary)
  56. The role of the mitogen-activated protein kinases (MAPKs) in endotoxin tolerance
    Sofie Vossius · 2007 · Document Server@UHasselt (UHasselt)
  57. Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa
    Anne Dettmann · 2012
  58. Molecular mechanisms and effector functions of the human cathelicidin host defence peptide LL-37: modulation of cytokine IL-32γ-induced responses and inflammatory arthritis
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  59. Update in Critical Care 2006
    Eric B Milbrandt, Akitoshi Ishizaka, Derek C. Angus · 2007 · American Journal of Respiratory and Critical Care Medicine
  60. The C-terminal non-catalytic domain of Mkp-1 phosphatase harbors a complex signal for rapid proteasome degradation in enterocytes
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  61. Estrategias para revertir la inmunosupresión en el fenómeno de tolerancia a endotoxinas
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  65. α, δ‑N‑Acetyl-glutamine Suppresses Neutrophilic Airway Inflammation by Activating the G Protein-Coupled Receptor/Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Phosphatase 1 Pathway.
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  66. Functions of stress-activated MAP kinases in the immune response
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