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Cited by 295Food Allergy and Anaphylaxis ResearchMast cells and histamineAsthma and respiratory diseases

IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity

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Forbes, Elizabeth E., Groschwitz, Katherine, Abonia, J. Pablo, Brandt, Eric B., Cohen, Elizabeth, Blanchard, Carine, Ahrens, Richard, Seidu, Luqman +7 more·2008·The Journal of Experimental Medicine
DOI 10.1084/jem.20071046PMC PMC2292227
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Abstract

Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9–deficient mice fail to develop experimental oral antigen–induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9–mediated mast cell responses have an important role in food allergy.

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Authors
Forbes, E. E., Groschwitz, K., Abonia, J. P., Brandt, E. B., Cohen, E., Blanchard, C., Ahrens, R., Seidu, L., McKenzie, A., Strait, R., Finkelman, F. D., Foster, P. S., Matthaei, K. I., Rothenberg, M. E., & Hogan, S. P.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • MRC Laboratory of Molecular Biology (GB)
  • University of Newcastle Australia (AU)
  • 6Gene Targeting Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Canberra 2601, Australia
ORCID
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2008-03-31
Volume
205
Issue
4
Pages
897-913
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20071046
PMC
PMC2292227
OpenAlex
W2109383966
Cited by
295
References
2
Citations by year
2026: 6 · 2025: 12 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 20 · 2018: 15 · 2017: 20 · 2016: 20 · 2015: 16 · 2014: 14 · 2013: 18 · 2012: 25
FWCI
15.81
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Funders
  • Fulbright New Zealand
  • Medical Research Council
  • National Health and Medical Research Council (224207)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
IL-9, mast cells, intestinal permeability, food allergy, intestinal anaphylaxis
MeSH terms
Administration, Oral, Anaphylaxis, Animals, Antigens, Disease Susceptibility, Cromolyn Sodium, Hypersensitivity, Intestines, Mast Cells, Mastocytosis, Mice, Transgenic, Ovalbumin, Permeability, Phenotype, Interleukin-9, Th2 Cells, Receptors, Interleukin-4, Gene Expression Profiling, Fatty Acid-Binding Proteins, STAT6 Transcription Factor, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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