Structural basis for complement factor H linked age-related macular degeneration

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Items 101–184 of 184

1. Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases
   Recalde, Sergio, Tortajada, Agustin, Subias, Marta, Anter, Jaouad, Blasco, Miquel, Maranta, Ramona, Coco, Rosa, Pinto, Sheila, Noris, Marina, García-Layana, Alfredo et al. · 2016 · Journal of the American Society of Nephrology
2. Smallpox Inhibitor of Complement Enzymes (SPICE): Dissecting Functional Sites and Abrogating Activity
   M. Kathryn Liszewski, Marilyn K. Leung, Richard E. Hauhart, Celia J. Fang, Paula G. Bertram, John P. Atkinson · 2009 · The Journal of Immunology
3. Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss
   Hee Young Cho, Han Sung Park, Eun Ju Ko, Chang Soo Ryu, Jung Oh Kim, Young Ran Kim, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim · 2019 · International Journal of Molecular Sciences
4. Complement Factor H Autoantibodies and Age-Related Macular Degeneration
   Baljean Dhillon, Alan F. Wright, Adnan Tufail, Isabel Y. Pappworth, Caroline Hayward, Iain Moore, Lisa Strain, David Kavanagh, Paul Nigel Barlow, Andrew P. Herbert et al. · 2010 · Investigative Ophthalmology & Visual Science
5. Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics
   Sanjay Ram, Jutamas Shaughnessy, Rosane B. DeOliveira, Lisa A. Lewis, Sunita Gulati, Peter A. Rice · 2017 · Pathogens and Disease
6. Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10
   Moussa A. Zouache, Alex Bennion, Jill L. Hageman, Christian P. Pappas, Burt T. Richards, Gregory S. Hageman · 2020 · Scientific Reports
7. Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion
   Andrew P. Herbert, David Kavanagh, Conny M. Johansson, Hugh P. Morgan, Bärbel S. Blaum, Jonathan P. Hannan, Paul Nigel Barlow, Dušan Uhrı́n · 2012 · Biochemistry
8. C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation
   Maurice Swinkels, Justine H. Zhang, Viranga Tilakaratna, Graeme Charles M. Black, Rahat Perveen, Selina McHarg, Antonio Inforzato, Anthony J. Day, Simon J. Clark · 2018 · Scientific Reports
9. Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
   Ami Miller, Anna Phillips, Jayesh Gor, Russell Wallis, Stephen J. Perkins · 2011 · Journal of Biological Chemistry
10. The lectin self of complement factor H
    Bärbel S. Blaum · 2017 · Current Opinion in Structural Biology
11. Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H
    Elisavet Makou, Haydyn D. T. Mertens, Mateusz Maciejewski, Dinesh C. Soares, Ilias Matis, Christoph Q. Schmidt, Andrew P. Herbert, Dmitri I. Svergun, Paul Nigel Barlow · 2012 · Journal of Molecular Biology
12. Common and rare genetic variants of complement components in human disease
    Elena Goicoechea de Jorge, Alberto López‐Lera, Rafael Bayarri‐Olmos, Hugo Yébenes, Margarita López‐Trascasa, Santiago Rodrı́guez de Córdoba · 2018 · Molecular Immunology
13. Complement genetics and susceptibility to inflammatory disease. Lessons from genotype–phenotype correlations
    Santiago Rodrı́guez de Córdoba · 2015 · Immunobiology
14. Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart
    Lisa A. Lewis, Peter A. Rice, Sanjay Ram · 2018 · Infection and Immunity
15. Meningococcal factor H binding protein as immune evasion factor and vaccine antigen
    Silvia Principato, Mariagrazia Pizza, Rino Rappuoli · 2020 · FEBS Letters
16. A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH‐related proteins 1–5 in human plasma
    Pingbo Zhang, Min Zhu, Minghui Geng-Spyropoulos, Michelle D Shardell, Marta González‐Freire, Vilmundur G. Gudnason, Guðný Eiríksdóttir, Debra Ann Schaumberg, Jennifer E. Van Eyk, Luigi Ferrucci et al. · 2016 · PROTEOMICS
17. Bivalent and co-operative binding of complement Factor H to heparan sulfate and heparin
    Sanaullah Khan, Ruodan Nan, Jayesh Gor, Barbara Mulloy, Stephen J. Perkins · 2012 · Biochemical Journal
18. Annexin A2 Enhances Complement Activation by Inhibiting Factor H
    Brandon Renner, Hua Hua Tong, Jennifer Laskowski, Karen R. Jonscher, Lindsey Goetz, Rachel A. Woolaver, Jonathan P. Hannan, Yong Xing Li, Dennis E. Hourcade, Matthew Caleb Pickering et al. · 2016 · The Journal of Immunology
19. Association Assessment of Copy Number Polymorphism and Risk of Age-Related Macular Degeneration
    Julie Sawitzke, Kate M. Im, Brittany N. Kostiha, Michael C. Dean, Bert Gold · 2011 · Ophthalmology
20. Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia
    Vinod Kumar, Ritambhra Nada, Raja Ramachandran, Amit Kumar Rawat, Karalanglin Tiewsoh, Reena Das, Charan Singh Rayat, Krishan Lal Gupta, Rakesh Kumar Vasishta · 2019 · Journal of Nephrology
21. Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease
    Daniel P. Miller, John V. McDowell, Jessica K. Bell, M. Paula Goetting‐Minesky, J. Christopher Fenno, Richard T. Marconi · 2014 · Molecular Oral Microbiology
22. Genotype‐phenotype correlations of low‐frequency variants in the complement system in renal disease and age‐related macular degeneration
    Maartje J. Geerlings, Elena B. Volokhina, Eiko K. de Jong, Nicole C. A. J. van de Kar, Marc Pauper, Carel B. Hoyng, Lambertus P. van den Heuvel, Anneke I. den Hollander · 2018 · Clinical Genetics
23. Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions
    Marco Mannes, Arthur Dopler, Markus Stefan Huber-Lang, Christoph Q. Schmidt · 2020 · Frontiers in Immunology
24. Multimeric Interactions between Complement Factor H and Its C3d Ligand Provide New Insight on Complement Regulation
    Azubuike I. Okemefuna, Keying Li, Ruodan Nan, Rebecca J. Ormsby, Tania A. Sadlon, David Gordon, Stephen J. Perkins · 2009 · Journal of Molecular Biology
25. Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines
    Wearn‐Xin Yee, Grace Barnes, Hayley Lavender, Christoph M. Tang · 2023 · Trends in Microbiology
26. Enabling methodology for the end functionalisation of glycosaminoglycan oligosaccharides
    Emiliano Gemma, Odile Meyer, Dušan Uhrı́n, Alison N. Hulme · 2008 · Molecular BioSystems
27. Clinicopathologic Implications of Complement Genetic Variants in Kidney Transplantation
    Zhen Ren, Stephen J. Perkins, Latisha D. Love-Gregory, John P. Atkinson, Anuja Java · 2021 · Frontiers in Medicine
28. A Novel Choroidal Endothelial Cell Line Has a Decreased Affinity for the Age-Related Macular Degeneration–Associated Complement Factor H Variant 402H
    Loeven, Markus A., van Gemst, Jasper J., Schophuizen, Carolien M. S., Tilakaratna, Viranga, van den Heuvel, Lambert P., Day, Anthony J., Klevering, B. Jeroen, van der Vlag, Johan · 2018 · Investigative Opthalmology & Visual Science
29. Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
    Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt · 2021 · Frontiers in Immunology
30. Unravelling protein–protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy
    Stephen J. Perkins, Azubuike I. Okemefuna, Ruodan Nan · 2010 · Biochemical Society Transactions
31. Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration
    Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Mario R. Romano, Antonio Inforzato · 2020 · Frontiers in Pharmacology
32. Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins
    Alexandra H. Antonioli, Janice White, Frances Crawford, Brandon Renner, Kevin J. Marchbank, Jonathan P. Hannan, Joshua M. Thurman, Philippa Marrack, Vernon Michael Holers · 2017 · The Journal of Immunology
33. Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) ofBorrelia burgdorferi
    Joseph J. E. Caesar, Reinhard Wallich, Peter Kraiczy, Peter F. Zipfel, Susan M. Lea · 2013 · Acta Crystallographica Section F Structural Biology and Crystallization Communications
34. Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation
    Makou, Elisavet, Herbert, Andrew P., Barlow, Paul N. · 2015 · Biochemical Society Transactions
35. Understanding the molecular basis of age-related macular degeneration and how the identification of new mechanisms may aid the development of novel therapies
    Anthony J. Day, Simon J. Clark, Paul N Bishop · 2011 · Expert Review of Ophthalmology
36. The effect of electrostatics on factor H function and related pathologies
    Chris A. Kieslich, Homero Vazquez, Gabrielle N. Goodman, Aliana López de Victoria, Dimitrios Morikis · 2011 · Journal of Molecular Graphics and Modelling
37. Treponema denticola: FhbB, Dentilisin, Complement Evasion and the Paradox of Factor H Cleavage
    John V. McDowell, Daniel P. Miller, Katherine L. Mallory, Richard T. Marconi · 2012 · Springer eBooks
38. ErpC, a member of the complement regulator-acquiring family of surface proteins fromBorrelia burgdorferi, possesses an architecture previously unseen in this protein family
    Joseph J. E. Caesar, Steven Johnson, Peter Kraiczy, Susan M. Lea · 2013 · Acta Crystallographica Section F Structural Biology and Crystallization Communications
39. C5a contributes to intraocular inflammation by affecting retinal pigment epithelial cells and immune cells
    M. Hu, B. Liu, S. Jawad, D. Ling, Megan Casady, Lai Wei, Robert Burton Nussenblatt · 2011 · British Journal of Ophthalmology
40. Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces
    Amy J. Osborne, Ruodan Nan, Ami Miller, Jayesh S. Bhatt, Jayesh Gor, Stephen J. Perkins · 2018 · Journal of Biological Chemistry
41. Alternative pathway amplification and infections
    Jutamas Shaughnessy, Aleyo Chabeda, Lisa A. Lewis, Sanjay Ram · 2022 · Immunological Reviews
42. Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration
    Laura A. Hecker, Albert O. Edwards · 2010 · Advances in experimental medicine and biology
43. Dense deposit disease and the factor H H402 allele
    Keith K. Lau, Richard J. Smith, Peter C. Kolbeck, Lavjay Butani · 2008 · Clinical and Experimental Nephrology
44. Energetic evaluation of binding modes in the C 3d and Factor H ( CCP 19‐20) complex
    Reed E. S. Harrison, Ronald D. Gorham, Dimitrios Morikis · 2015 · Protein Science
45. How novel structures inform understanding of complement function
    Elena Goicoechea de Jorge, Hugo Yébenes, Marina Serna, Agustín Tortajada, Óscar Llorca, Santiago Rodrı́guez de Córdoba · 2017 · Seminars in Immunopathology
46. Molecular Mechanisms of Macular Degeneration Associated with the Complement Factor H Y402H Mutation.
    Reed E. S. Harrison, D. Morikis · 2019 · Biophysical Journal
47. Investing in vision: Innovation in retinal therapeutics and the influence on venture capital investment
    Dmitrij Hristodorov, Tim Lohoff, Nanna L. Lüneborg, Geert-Jan Mulder, Simon J. Clark · 2024 · Progress in Retinal and Eye Research
48. Putting the structure into complement
    Susan M. Lea, Steven Johnson · 2012 · Immunobiology
49. Probing the solution structure of Factor H using hydroxyl radical protein footprinting and cross-linking
    Anna Baud, Florence Gonnet, Isabelle Salard, Maxime Le Mignon, Alexandre Giuliani, Pascal Mercère, Bianca Sclavi, Régis Daniel · 2016 · Biochemical Journal
50. Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms
    Paul Nigel Barlow, Gregory S. Hageman, Susan M. Lea · 2008 · Advances in experimental medicine and biology
51. Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines
    Hayley Lavender, Katy Poncin, Christoph M. Tang · 2017 · Infection and Immunity
52. In self-defense
    Piet Gros · 2011 · Nature Structural & Molecular Biology
53. Montgomery's tubercles. Sebaceous glands.
    A. B. Ackerman, Neal S. Penneys · 1971 · PubMed
54. With phases: how two wrongs can sometimes make a right
    Pietro Roversi, Steven Johnson, Susan M. Lea · 2010 · Acta Crystallographica Section D Biological Crystallography
55. Reply to “Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent”
    Anne E. Hughes, Nick Orr, Heather Jane Cordell, Timothy H.J. Goodship · 2010 · Nature Genetics
56. A potential bimodal interplay between heme and complement factor H 402H in the deregulation of the complement alternative pathway by SARS-CoV-2
    Stefanos A. Tsiftsoglou, Eleni Gavriilaki · 2024 · Infection Genetics and Evolution
57. The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H
    Jaclyn Swan, Christopher B. Toomey, Max Bergstrand, Héctor Cuello, Jesse Robie, Hai Yu, Yue Hua Yuan, Anoopjit Singh Kooner, Xi Chen, Jutamas Shaughnessy et al. · 2025 · Investigative Ophthalmology & Visual Science
58. Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis
    Takanori Yokoo, Aki Tanabe, Yoko Yoshida, José M. M. Caaveiro, Makoto Nakakido, Yoichiro Ikeda, Yoshihiro Fujimura, Masanori Matsumoto, Kevin C. Entzminger, Toshiaki Maruyama et al. · 2022 · Journal of Biological Chemistry
59. Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches
    Peter F. Zipfel, Nadine Lauer · 2012 · Advances in experimental medicine and biology
60. Complement Control Proteins and Receptors: From FH to CR4
    Robert B. Sim, Beryl E. Moffatt, Jacqueline M. Shaw, Janez Ferluga · 2008 · Royal Society of Chemistry eBooks
61. Gene polymorphism of complement factor H in a Turkish patient with membranoproliferative glomerulonephritis type II.
    Betül Sözeri, Sevgı Mır, Afig Berdelı, Nida Dinçel, Banu Sarsık · 2012 · Iranian Journal of Kidney Diseases
62. An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration
    Robyn M. Biggs, Elisavet Makou, Scott Lauder, Andrew P. Herbert, Paul Nigel Barlow, Suresh K. Katti · 2022 · Investigative Ophthalmology & Visual Science
63. Animal Models for Age-Related Macular Degeneration
    Joe G. Hollyfield, Lisa A. Kuttner-Kondo · 2009 · Neuromethods
64. The Role of Inflammation in Age-Related Macular Degeneration
    James M. Harris, David M. Wu · 2025 · International Ophthalmology Clinics
65. Complement Regulators and Inhibitors in Health and Disease: A Structural Perspective
    Laure Yatime, Goran Bajic, Janus Asbjørn Schatz-Jakobsen, Gregers Rom Andersen · 2016 · Advances in delivery science and technology
66. Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
    Lazara Elena Santiesteban-Lores, Leonardo Moura Midon, ThirsaAlvares Franco, Luciano Marcondes de Oliveira, Sumire Hibi, Yosena Chiani, Gdayllon Cavalcante Meneses, Elizabeth De Francesco Daher, Denise Moraes Fonseca, Alessandra Pontillo et al. · 2024 · Immunogenetics
67. Hyaluronan-Binding Proteins in Inflammation
    Anthony J. Day, Charles D. Blundell, David J. Mahoney, Marilyn S. Rugg, Caroline M. Milner · 2008 · Royal Society of Chemistry eBooks
68. Association of Complement Factor H (CFH) Y402H Gene Polymorphism and Serum CFH with Risk of Age Related Macular Degeneration in Egyptian Patients
    M.D. NAHLA A. FAWZY MARIANNE S.M. ISSAC, M.D. MOHAMED A. ZAYED RIHAM A. El-ESSAWY · 2019 · The Medical Journal of Cairo University/The Medical Journal of Cairo University
69. Probing protein-ligand interactions via solution phase hydrogen exchange mass spectrometry
    Stefan T. Esswein · 2010 · ERA
70. Complement Factor H: solution structures and interactions with ligands
    Azubuike I. Okemefuna · 2009 · UCL Discovery (University College London)
71. Macular degeneration: Getting the GAG
    Mirko von Elstermann · 2007 · Functional Glycomics
72. Funktionelle Charakterisierung der mit altersabhängiger Makuladegeneration (AMD) assoziierten Komplementfaktor-H-Variante Y402H
    Florian Börncke · 2012
73. Efeito da curcumina na secreção de fator H mutante em paciente deficiente desta proteína reguladora do sistema complemento.
    Ana Catarina Lunz Macedo · 2018
74. Molecular principles of enhanced complement activation by properdin
    Ramon M. van den Bos · 2021
75. A Personal Tribute to Robert B. Sim with Reflections on Our Work Together on Factor H
    Anthony J. Day · 2021 · Viruses
76. Therapy in pipeline for age-related macular degeneration
    Weiye Li · 2021 · Elsevier eBooks
77. Faculty Opinions recommendation of A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.
    Toshiyuki Miyata · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
78. A holistic approach to eye care part 2: Age-related macular degeneration; an inflammatory disease
    Rohit Narayan · 2020 · Optician
79. Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy
    Jacob H. J. Betts, Katherine Hampton, Dudley K. Strickland, Simon J. Clark, Anthony J. Day, Linda Troeberg · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
80. Evidence for the Pathogenicity of a CFH Variant in a Multigenerational Family with Cuticular Drusen
    Eglė Preikšaitienė, Viktorija Gurskytė, Violeta Mikštienė, Rasa Strupaitė-Šileikienė, Ramūnas Dzindzalieta, Gunda Petraitytė, Justas Dapkūnas, Enrika Vyčaitė, Dovilė Karčiauskaitė, Linas Černiauskas et al. · 2025 · Medicina
81. Additional file 1 of Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci
    Pappas, Chris M., Moussa A. Zouache, Stacie Matthews, Caitlin D. Faust, Jill L. Hageman, Brandi L. Williams, Burt T. Richards, Gregory S. Hageman · 2021 · Figshare
82. Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes
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83. Complement Factor H‐Based Therapeutics: A Comprehensive Overview
    Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw · 2026 · European Journal of Immunology
84. Complement Factor H C-terminus and its significance : a structural narrative
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