The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Fibroblast heterogeneity in the cancer wound
Open accessAbstract
Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.
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Cites
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“Fibroblasts are essential in tissue homeostasis and wound healing, and consistent with the hypothesis that “a tumor is a wound that never heals” (Dvorak, 1986), an emerging body of evidence demonstrates that the fibroblasts in tumors, often referred to as cancer-associated fibroblasts (CAFs), are…”
BackgroundMyofibroblasts and mechano-regulation of connective tissue remodelling
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Self-citationTumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
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Cited by
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590
Self-citationEMT, CSCs, and drug resistance: the mechanistic link and clinical implications
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Self-citationAntiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589
Metadata
- Authors
- Öhlund, D., Elyada, E., & Tuveson, D.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-07-28
- Volume
- 211
- Issue
- 8
- Pages
- 1503-1523
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2139788242
- Cited by
- 926
- References
- 43
- FWCI
- 26.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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