The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling
Open accessAbstract
Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor microenvironment. Systemic administration of Bifidobacterium leads to its accumulation within the tumor and converts the nonresponder mice into responders to anti-CD47 immunotherapy in a stimulator of interferon genes (STING)– and interferon-dependent fashion. Local delivery of Bifidobacterium potently stimulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatment. Our study identifies the mechanism by which gut microbiota preferentially colonize in tumor sites and facilitate immunotherapy via STING signaling.
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Citations
Cites
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“Primer sets included two primers, BifidF (59-CGGGTGAGTAAT GCGTGACC-39) and BifidR (59-TGATAGGACGCGACCCCA-39), and one probe (59-6FAM-CTCCTGGAAACGGGTG-39; Sivan et al., 2015).”
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Matson, V., Fessler, J., Bao, R., Chongsuwat, T., Zha, Y., Alegre, M.-L., Luke, J. J., & Gajewski, T. F. (2018) · Science · doi:10.1126/science.aao3290 · Cited by 3,107 · cited 4×
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BackgroundInfluentialCommensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
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Cited by
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Mager, L. F., Burkhard, R., Pett, N., Cooke, N. C. A., Brown, K., Ramay, H., Paik, S., Stagg, J., Groves, R. A., Gallo, M., et al. (2020) · Science · doi:10.1126/science.abc3421 · Cited by 1,407
The microbiome and human cancer
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The updated landscape of tumor microenvironment and drug repurposing
Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer
Fu, A., Yao, B., Dong, T., Chen, Y., Yao, J., Liu, Y., Li, H., Bai, H., Liu, X., Zhang, Y., et al. (2022) · Cell · doi:10.1016/j.cell.2022.02.027 · Cited by 981
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Self-citation
Metadata
- Authors
- Shi, Y., Zheng, W., Yang, K., Harris, K. G., Ni, K., Xue, L., Lin, W., Chang, E. B., Weichselbaum, R. R., & Fu, Y.-X.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2020-03-06
- Volume
- 217
- Issue
- 5
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W3009785090
- Cited by
- 409
- References
- 37
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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