The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine
Open accessAbstract
Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine–associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-α2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination.
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A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Béziat, V., et al. (2020) · Science · doi:10.1126/science.abd4585 · Cited by 2,662
Self-citationInborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., Ogishi, M., Sabli, I. K. D., Hodeib, S., Korol, C., et al. (2020) · Science · doi:10.1126/science.abd4570 · Cited by 2,229
Self-citationShared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Meager, A., Visvalingam, K., Peterson, P., Möll, K., Murumägi, A., Krohn, K., Eskelin, P., Perheentupa, J., Husebye, E., Kadota, Y., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030289 · Cited by 453
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Self-citationBastard, P., Orlova, E., Sozaeva, L., Lévy, R., James, A., Schmitt, M. M., Ochoa, S., Kareva, M., Rodina, Y., Gervais, A., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210554 · Cited by 299
Self-citationA loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes
Bastard, P., Hsiao, K.-C., Zhang, Q., Choin, J., Best, E., Chen, J., Gervais, A., Bizien, L., Materna, M., Harmant, C., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20220028 · Cited by 70
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Metadata
- Authors
- Bastard, P., Michailidis, E., Hoffmann, H.-H., Chbihi, M., Le Voyer, T., Rosain, J., Philippot, Q., Seeleuthner, Y., Gervais, A., Materna, M., de Oliveira, P. M. N., Maia, M. D. L. S., Dinis Ano Bom, A. P., Azamor, T., Araújo da Conceição, D., Goudouris, E., Homma, A., Slesak, G., Schäfer, J., Pulendran, B., Miller, J. D., Huits, R., Yang, R., Rosen, L. B., Bizien, L., Lorenzo, L., Chrabieh, M., Erazo, L. V., Rozenberg, F., Jeljeli, M. M., Béziat, V., Holland, S. M., Cobat, A., Notarangelo, L. D., Su, H. C., Ahmed, R., Puel, A., Zhang, S.-Y., Abel, L., Seligman, S. J., Zhang, Q., MacDonald, M. R., Jouanguy, E., Rice, C. M., & Casanova, J.-L.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-02-05
- Volume
- 218
- Issue
- 4
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W3127394181
- Cited by
- 247
- References
- 5
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bastard, P., Michailidis, E., Hoffmann, H.-H., Chbihi, M., Le Voyer, T., Rosain, J., Philippot, Q., Seeleuthner, Y., Gervais, A., Materna, M., de Oliveira, P. M. N., Maia, M. D. L. S., Dinis Ano Bom, A. P., Azamor, T., Araújo da Conceição, D., Goudouris, E., Homma, A., Slesak, G., Schäfer, J., . . . Casanova, J.-L. (2021). Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20202486
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