Alzheimer mutant speeds APP transport
Open accessAbstract
APPS198P segregates with rare familial forms of Alzheimer’s disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210313) show that the brains of APPS198P transgenic mice accumulate excess levels of Aβ. In cultured cells, APPS198P undergoes accelerated ER folding, leading to early arrival in late vesicular compartments, thereby enhancing generation of Aβ.
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Amyloid plaques represent a pathological hallmark of AD.
“Amyloid plaques represent a pathological hallmark of AD3”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [3]
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- Authors
- Gandy, S., & Ehrlich, M. E.
- Affiliations
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Gandy, Sam
- Ehrlich, Michelle E.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-05-14
- Volume
- 218
- Issue
- 6
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC8129791
- OpenAlex
- W3160141476
- Cited by
- 3
- References
- 20
- Citations by year
- 2024: 1 · 2022: 2
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (MPI U01 AG046170, R01 AG057907, MPI RF1 AG058469, MPI RF1 AG059319, MPI R01 AG061894)
- NIA-Designated Mount Sinai Alzheimer’s Disease Research Center (P30 AG066514)
- The Sara and Gideon Gartner Foundation
- The Louis B. Mayer Foundation
- The Linda Wachner Foundation
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta deposition, late endosomes, familial Alzheimer's disease, transgenic mice
- MeSH terms
- Alzheimer Disease, Animals, Brain, Exons, Mice, Transgenic, Amyloid beta-Peptides, Mice
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