Friend turned foe: TREM2 agonist in battles against tau
Open accessAbstract
In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer’s disease tau.
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TREM2-related microglial activation may support amyloid plaque engagement.
“TREM2-related microglial activation may support amyloid plaque engagement”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [56]
The role of TREM2-related microglial activation in tau-dominant or later-stage disease is more controversial.
“its role in tau-dominant or later-stage disease is more controversial”
From Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis? (2026) · cites this paper as [56]
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References 17 · Cited by 8
Research works printed but not linked: 11
- Dhandapani, R.,. 2022. Cell Rep. 10.1016/j.celrep.2022.110883 · DOI · Paper page
- Guerreiro, R.,. 2013. N. Engl. J. Med. 10.1056/NEJMoa1211851 24143816 · DOI · Paper page
- Jain, N.,. 2022. J. Exp. Med. 10.1084/jem.20220654 · DOI · Paper page
- Jonsson, T.,. 2013. N. Engl. J. Med. 10.1056/NEJMoa1211103 24131183 · DOI · Paper page
- Leyns, C.E.G.,. 2019. Nat. Neurosci. 10.1038/s41593-019-0433-0 PMC6660358 31235932 · DOI · Paper page
- Morenas-Rodríguez, E.,. 2022. Lancet Neurol. 10.1016/S1474-4422(22)00027-8 · DOI
- Price, B.R.,. 2020. J. Neuroinflammation. 10.1186/s12974-020-01915-0 · DOI
- Wang, S.,. 2020. J. Exp. Med. 10.1084/jem.20200785 · DOI · Paper page
- Yuan, P.,. 2016. Neuron. 10.1016/j.neuron.2016.05.003 · DOI · Paper page
- Zhao, P.,. 2022. Sci. Transl. Med. 10.1126/scitranslmed.abq0095 · DOI · Paper page
- Zhong, L.,. 2019. Nat. Commun. 10.1038/s41467-019-09118-9 · DOI · Paper page
- Authors
- Carling, G., Luo, W., & Gan, L.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Gan, Li
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2022-11-18
- Volume
- 220
- Issue
- 1
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC9680035
- OpenAlex
- W4309296396
- Cited by
- 8
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- tau seeding, tau spread, Alzheimer's disease, microglia, 5xFAD mice, TREM2
- MeSH terms
- Alzheimer Disease, Animals, Graft vs Host Disease, Humans, Membrane Glycoproteins, Receptors, Immunologic, Microglia, Friends, Mice
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