LIPOIDS AS THE GROWTH-INHIBITING FACTOR IN SERUM
Open accessAbstract
The growth-inhibiting action of serum has been shown to be due largely to the lipoids. Serum from which the lipoids have been removed is much less inhibiting to the growth of fibroblasts in vitro than is the original serum, and only slightly more inhibiting than Tyrode solution. The lipoids extracted from the serum are toxic and more inhibiting to the growth of fibroblasts than the original serum. Lipoids extracted from chicken brain, chicken liver, egg, and embryonic tissue have likewise an inhibiting action.
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Blood plasma and embryo juice are organic complexes of unknown constitution, and attempts to elucidate their makeup have not been especially successful.
“Blood plasma and embryo juice are organic complexes of unknown constitution, and such attempts as have been made to elucidate their makeup have not been especially successful”
From A handbook of plant tissue culture, by Philip R. White... (1943) · cites this paper as Baker and Carrel, 1925, 195
The experimental-methods passage (pp. 143–145) uses plasma and embryonic tissue juice as culture-medium ingredients, while the discussion (pp. 152–153) says further work is needed to identify the inhibiting serum lipoid. Neither passage characterizes both materials as complexes of unknown constitution or assesses whether attempts to determine their makeup have been successful. Searches for those descriptions found no supporting passage in our copy. (LLM, conf=0.72)
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A handbook of plant tissue culture, by Philip R. White...
White, P. R. (1943) · doi:10.5962/bhl.title.4656 · Cited by 434 · see citing works
- Authors
- Baker, L. E., & Carrel, A.
- Affiliations
- From the Laboratories of The Rockefeller Institute for Medical Research.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1925-08-01
- Volume
- 42
- Issue
- 2
- Pages
- 143-154
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2131004
- OpenAlex
- W2081224709
- Cited by
- 30
- References
- 0
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- lipoids, serum lipids, growth inhibition, fibroblast proliferation, serum toxicity, chicken brain, chicken liver, eggs, embryonic tissue
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