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CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS
Open accessAbstract
It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera. The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors. If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly. Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64. The titer of the neutralizing antibodies increases in the course of immunization. Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates.
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Citations
Cited by
Peltola, H. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.2.302-317.2000 · Cited by 1,364
Solís, D., Bovin, N. V., Davis, A. P., Jiménez-Barbero, J., Romero, A., Roy, R., Smetana, K., & Gabius, H.-J. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.03.016 · Cited by 222
Recent trends on the molecular biology of pneumococcal capsules, lytic enzymes, and bacteriophage
López, R., & García, E. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.05.002 · Cited by 187
Metadata
- Authors
- Goebel, W. F., & Avery, O. T.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1929-10-01
- Volume
- 50
- Issue
- 4
- Pages
- 521-531
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2528509820
- Cited by
- 283
- References
- 0
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS. https://app.cochat.ai/papers/10.1084/jem.50.4.521
- The paper
- Goebel, W. F., & Avery, O. T. (1929). CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS. Journal of Experimental Medicine. https://doi.org/10.1084/jem.50.4.521
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
