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Cited by 28Influenza Virus Research StudiesPneumonia and Respiratory InfectionsRespiratory viral infections research

SULFONAMIDE CHEMOTHERAPY OF COMBINED INFECTION WITH INFLUENZA VIRUS AND BACTERIA

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Harford, Carl G., Smith, Mary Ruth, Wood, W. Barry·1946·Journal of Experimental Medicine
DOI 10.1084/jem.83.6.505PMC PMC2135587
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Abstract

1. Sulfonamide chemotherapy controls the bacterial component of combined infection with influenza virus and pneumococci in rats. 2. Reinstillation of fluid (broth, physiological salt solution) into the respiratory passages of mice several days after sublethal viral infection converts the viral infection into a lethal one. 3. Sulfonamide chemotherapy controls the bacterial component of combined bacterial and viral infection of mice, produced by intrabronchial inoculation of mixtures of bacteria and sublethal or lethal doses of virus. 4. Bacterial pneumonia may be superimposed upon sublethal viral infection in mice by inhalation of fine droplets of bacterial suspension several days after inoculation of virus. Normal mice inhaling fine droplets of bacterial suspension fail to develop obvious disease. 5. Sulfonamide chemotheiapy controls bacterial pneumonia superimposed on sublethal viral infection by inhalation of fine droplets of bacterial culture. 6. The secondary bacterial penumonia does not convert the sublethal viral infection into a lethal one. 7. If another pandemic of influenza occurs, it is probable that sulfonamide chemotherapy will be valuable in the treatment of secondary bacterial pneumonia and will be effective in lowering the case fatality rate if the viral component of the infection is not severe enough by itself to cause death.

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  • During the 1940s, studies in ferrets, mice, and rats established that influenza virus combined with any of several pneumopathic bacteria acted synergistically to produce higher disease incidence, higher death rate, or shortened time to death; antibiotics given shortly after combined infection mitigated or eliminated these effects.

    “During the 1940s, additional studies in ferrets, mice, and rats established that the influenza virus in combination with any of several pneumopathic bacteria acted synergistically to produce either a higher incidence of disease, a higher death rate, or a shortened time to death [70-73]; these effects could be mitigated or eliminated if antibiotics were given shortly after establishment of combined”

    From Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness (2008) · cites this paper as [73]

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References 24 · Cited by 28

Research works printed but not linked: 47

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Authors
Harford, C. G., Smith, M. R., & Wood, W. B.
Affiliations
Washington University in St. Louis (US)
Venue
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
1946-06-01
Volume
83
Issue
6
Pages
505-518
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.83.6.505
PMC
PMC2135587
OpenAlex
W2099647752
Cited by
28
References
24
Citations by year
2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2013: 1
FWCI
7.80
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
influenza virus, Streptococcus pneumoniae, secondary bacterial pneumonia, viral-bacterial coinfection, reinfection, case fatality rate, pandemic influenza, respiratory infections

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