The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons
Open accessAbstract
Previous studies suggested that tetrodotoxin, a poison from the puffer fish, blocks conduction of nerve and muscle through its rather selective inhibition of the sodium-carrying mechanism. In order to verify this hypothesis, observations have been made of sodium and potassium currents in the lobster giant axons treated with tetrodotoxin by means of the sucrose-gap voltage-clamp technique. Tetrodotoxin at concentrations of 1 x 10-7 to 5 x 10-9 gm/ml blocked the action potential but had no effect on the resting potential. Partial or complete recovery might have occurred on washing with normal medium. The increase in sodium conductance normally occurring upon depolarization was very effectively suppressed when the action potential was blocked after tetrodotoxin, while the delayed increase in potassium conductance underwent no change. It is concluded that tetrodotoxin, at very low concentrations, blocks the action potential production through its selective inhibition of the sodium-carrying mechanism while keeping the potassium-carrying mechanism intact.
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Citations
Cites
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004717 · Cited by 2,491
The action of calcium on the electrical properties of squid axons
Frankenhaeuser, B., & Hodgkin, A. L. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005808 · Cited by 1,834
Measurement of current‐voltage relations in the membrane of the giant axon of Loligo
Hodgkin, A. L., Huxley, A. F., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004716 · Cited by 1,733
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004719 · Cited by 1,600
The components of membrane conductance in the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004718 · Cited by 1,401
Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres
Weidmann, S. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005379 · Cited by 700
Delayed Rectification and Anomalous Rectification in Frog's Skeletal Muscle Membrane
Nakajima, S., Iwasaki, S., & Obata, K. (1962) · The Journal of General Physiology · doi:10.1085/jgp.46.1.97 · Cited by 144
Membrane Potentials of the Lobster Giant Axon Obtained by Use of the Sucrose-Gap Technique
Julian, F. J., Moore, J. W., & Goldman, D. E. (1962) · The Journal of General Physiology · doi:10.1085/jgp.45.6.1195 · Cited by 124
Self-citationEFFECT OF TETRODOTOXIN ON THE MAMMALIAN NEURO-MUSCULAR SYSTEM
Kuriaki, K., & WADA, I. (1957) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.7.35 · Cited by 5
Cited by
The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres
Attwell, D., Cohen, I., Eisner, D., Ohba, M., & Ojeda, C. (1979) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00586939 · Cited by 458
Rat optic nerve: electrophysiological, pharmacological and anatomical studies during development
Foster, R. E., Connors, B. W., & Waxman, S. G. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90005-0 · Cited by 278
Burke, R. E., & Rudomin, P. (1977) · Comprehensive Physiology · doi:10.1002/cphy.cp010124 · Cited by 276
Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future
Narahashi, T. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39034-2 · Cited by 257
Self-citationGlutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery
Vazana, U., Veksler, R., Pell, G. S., Prager, O., Fassler, M., Chassidim, Y., Roth, Y., Shahar, H., Zangen, A., Raccah, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-16.2016 · Cited by 205
Metadata
- Authors
- Narahashi, T., Moore, J. W., & Scott, W. R.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1964-05-01
- Volume
- 47
- Issue
- 5
- Pages
- 965-974
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2061904925
- Cited by
- 1,081
- References
- 9
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons. https://app.cochat.ai/papers/10.1085/jgp.47.5.965
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- Narahashi, T., Moore, J. W., & Scott, W. R. (1964). Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons. The Journal of General Physiology. https://doi.org/10.1085/jgp.47.5.965
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
