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The Mechanism of the Action of Caffeine on Sarcoplasmic Reticulum
Open accessAbstract
Evidence is presented that caffeine does not act on the mitochondrial Ca uptake system and that its effect cannot be attributed to the accumulation of adenosine 3',5'-phosphate. Two distinct caffeine effects are described. At high ATP concentrations caffeine decreases the coupling between ATP hydrolysis and Ca inflow. It either inhibits inflow without any inhibition of the rate of ATP hydrolysis, or it stimulates the ATPase activity without stimulating Ca inflow. These high ATP concentrations (much higher than needed for the saturation of the transport ATPase) greatly reduce the control of the turnover rate of the transport system, by accumulated Ca. At low ATP concentrations when the transport system is under maximal control by accumulated Ca, caffeine inhibits the ATPase activity without affecting the rate of Ca inflow.
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Citations
Cites
Respiration-dependent accumulation of inorganic phosphate and Ca++ by rat liver mitochondria
Lehninger, A. L., Rossi, C. S., & Greenawalt, J. W. (1963) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(63)90377-2 · Cited by 188
Cited by
Weber, A., & Herz, R. (1968) · The Journal of General Physiology · doi:10.1085/jgp.52.5.750 · Cited by 678
Self-citationEffect of caffeine on the neuromuscular system — potential as an ergogenic aid
Tarnopolsky, M. A. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-121 · Cited by 187
Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus
Ríos, E. (2018) · Journal of General Physiology · doi:10.1085/jgp.201711959 · Cited by 103
Metadata
- Authors
- Weber, A.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1968-11-01
- Volume
- 52
- Issue
- 5
- Pages
- 760-772
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2128903096
- Cited by
- 296
- References
- 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
