Combining the Sibling Disequilibrium Test and Transmission/Disequilibrium Test for Multiallelic Markers
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Within-family genetic association estimates, such as those obtained from samples of siblings, can provide less biased estimates of direct genetic effects because they are unlikely to be affected by demographic and indirect genetic effects of parents.
“Within-family genetic association estimates, such as those obtained from samples of siblings, can provide less biased estimates of direct genetic effects because they are unlikely to be affected by demographic and indirect genetic effects of parents7,17,30–34.”
From Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects (2022) · cites this paper as [34]
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Research works printed but not linked: 6
- [1]1. Bickel, PJ On some asymptotic competitors to Hotelling's T2 Ann Math Stat. 1965; 36:160-173 Crossref Google Scholar
- [2]2. Bradley, RA ∙ Terry, ME Rank analysis of incomplete block designs. I. The method of paired comparisons Biometrika. 1952; 39:324-345 Crossref Google Scholar
- [3]3. Curtis, D Use of siblings as controls in case-control association studies Ann Hum Genet. 1997; 61:319-333 Crossref Scopus (176) PubMed Google Scholar
- [4]4. Curtis, D ∙ Sham, PC A note on the application of the transmission disequilibrium test when a parent is missing Am J Hum Genet 1995. 1995; 56:811-812 Google Scholar
- [5]5. Horvath, S ∙ Laird, NM A discordant-sibship test for disequilibrium and linkage: no need for parental data Am J Hum Genet. 1998; 63:1886-1897 Full Text Full Text (PDF) Scopus (185) PubMed Google Scholar
- [6]6. Martin, ER ∙ Kaplan, NL ∙ Weir, BS Tests for linkage and association in nuclear families Am J Hum Genet. 1997; 61:439-448
Cited by
Sorted by citations
Family-based designs in the age of large-scale gene-association studies
Laird, N., & Lange, C. (2006) · Nature reviews genetics · doi:10.1038/nrg1839 · Cited by 477 · see citing works
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Howe, L. J., Nivard, M. G., Morris, T. T., Hansen, A. F., Rasheed, H., Cho, Y., Chittoor, G., Ahlskog, R., Lind, P. A., Palviainen, T., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01062-7 · Cited by 377 · see citing works
Human population structure and genetic association studies.
Ziv, E., & Burchard, E. (2003) · Pharmacogenomics (London) · doi:10.1517/phgs.4.4.431.22758 · Cited by 127 · see citing works
Sneller, C., Mather, D. E., & Crepieux, S. (2009) · Crop Science · doi:10.2135/cropsci2008.07.0420 · Cited by 52 · see citing works
“The TDT has been further adapted to quantitative traits, nuclear families of varying size, missing parents, and use of various relatives as controls (Abecasis et al., 2000; Allison, 1997; Curtis et al., 1999; George et al., 1999; Horvath and Laird, 1998; Martin et al., 2000; Rabinowitz, 1997; Rabinowitz and Laird, 200…”
MethodHandoko, H., Nancarrow, D., Hayward, N. K., Ohaeri, J. U., Aghanwa, H., McGrath, J., Levinson, D., Johns, C., Walters, M., Nertney, D., et al. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20059 · Cited by 41
“(1) a case-control comparison of the TNF haplotypes using CLUMP [Sham and Curtis, 1995a] and (2) the SDT test [Curtis et al., 1999], both of which output appropriately calculated P-values.”
MethodFamily-based association studies
Zhao, H. (2000) · Statistical Methods in Medical Research · doi:10.1177/096228020000900604 · Cited by 79 · see citing works
Joint Tests of Linkage and Association for Quantitative Traits
Allison, D. B., & Neale, M. C. (2001) · Theoretical Population Biology · doi:10.1006/tpbi.2001.1544 · Cited by 16 · see citing works
“After the development of the original TDT, several investigators realized that they could construct legitimate tests of linkage in the presence of association for dichotomous traits even when no parental data were available by relying on sibling data (Boehnke and Langefeld, 1998; Curtis, 1997; Curtis et al., 1999; Ewe…”
MethodAssortative mating and within-spouse pair comparisons
Howe, L. J., Battram, T., Morris, T., Hartwig, F. P., Hemani, G., Davies, N. M., & Smith, G. D. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009883 · Cited by 16 · see citing works
Using all alleles in the multiallelic versions of the SDT and combined SDT/TDT.
Czika, W., & Berry, J. J. (2002) · American Journal of Human Genetics · doi:10.1086/344290 · Cited by 5 · see citing works
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
Self-citation
- Authors
- Curtis, D., Miller, M. B., & Sham, P. C.
- Affiliations
- Queen Mary University of London (GB)
- University of Missouri (US)
- Corresponding author
- Curtis, David
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 64
- Issue
- 6
- Pages
- 1785-1786
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1377924
- OpenAlex
- W2002923646
- Cited by
- 13
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- transmission disequilibrium test, multiallelic markers, affected sibships, genetic association
- MeSH terms
- Alleles, Genetic Markers, Humans, Nuclear Family, Linkage Disequilibrium
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