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Cited by 117Forensic and Genetic ResearchGenetic diversity and population structureRace, Genetics, and Society

mtDNA Affinities of the Peoples of North-Central Mexico

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Green, Lance D., Derr, James N., Knight, Alec·2000·The American Journal of Human Genetics
DOI 10.1086/302801PMC PMC1288179
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Abstract

mtDNA haplotypes of representatives of the cosmopolitan peoples of north-central Mexico were studied. Two hundred twenty-three samples from individuals residing in vicinities of two localities in north-central Mexico were analyzed. A combination of strategies was employed to identify the origin of each haplotype, including length variation analysis of the COII and tRNALYS intergenic region, nucleotide sequence analysis of control region hypervariable segment 1, and RFLP analysis of PCR products spanning diagnostic sites. Analysis of these data revealed that the majority of the mtDNA haplotypes were of Native American origin, belonging to one of four primary Native American haplogroups. Others were of European or African origin, and the frequency of African haplotypes was equivalent to that of haplotypes of European derivation. These results provide diagnostic, discrete character, molecular genetic evidence that, together with results of previous studies of classical genetic systems, is informative with regard to both the magnitude of African admixture and the relative maternal contribution of African, European, and Native American peoples to the genetic heritage of Mexico. Phylogenetic analysis revealed that African sequences formed a basal, paraphyletic group.

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  • Latinos across the Americas have differing proportions of Native American, African, and European genetic ancestry, shaped by local historical interactions with migrants brought by the slave trade, European settlement, and indigenous Native American populations.

    “Latinos across the Americas have differing proportions of Native American, African, and European genetic ancestry, shaped by local historical interactions with migrants brought by the slave trade, European settlement, and indigenous Native American populations.12–18”

    From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [14]

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  • Consistent with previous studies, Latinos have 13% less European ancestry on the X chromosome than genome-wide, showing proportionally greater European ancestry contributions from males.

    “Consistent with previous studies that show a sex bias in admixture in Latino populations,12–18 we estimate 13% less European ancestry on the X chromosome than genome-wide (Table 1), showing proportionally greater European ancestry contributions from males.”

    From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [14]

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Cited by

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Authors
Green, L. D., Derr, J. N., & Knight, A.
Affiliations
  • Los Alamos National Laboratory (US)
  • Texas A&M University (US)
  • Sul Ross State University (US)
Corresponding author
Green, Lance D.
ORCID
Derr, James N.
Venue
The American Journal of Human Genetics
Publisher
Elsevier BV
Published
2000-03
Volume
66
Issue
3
Pages
989-998
ISSN
0002-9297 (ISSN-L)
DOI
10.1086/302801
PMC
PMC1288179
OpenAlex
W2111398267
Cited by
117
References
0
Citations by year
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FWCI
2.34
Type
journal article
Language
en
Open access
Licence
Locations
  • The American Journal of Human Genetics (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Texas Tech University
  • University of Texas at El Paso
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
Keywords
mitochondrial haplotypes, north-central Mexico, African admixture, European admixture, maternal ancestry, RFLP markers, population structure
MeSH terms
Africa, Electron Transport Complex IV, DNA, Mitochondrial, Europe, Female, Gene Frequency, Genetic Markers, Haplotypes, Humans, Indians, North American, Mexico, Phylogeny, Polymorphism, Restriction Fragment Length, RNA, Transfer, Lys, Genetic Variation, Sequence Deletion

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