The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The epidemiology of candidemia in two United States cities: results of a population-based active surveillance.
Abstract
We conducted prospective, active population-based surveillance for candidemia (defined as any Candida species isolated from blood) in Atlanta and San Francisco (total population, 5.34 million) during 1992-1993. The average annual incidence of candidemia at both sites was 8 per 100,000 population. The highest incidence (75 per 100,000) occurred among infants </=1 year old. In 19% of patients, candidemia developed prior to or on the day of admission. Underlying medical conditions included cancer (26%), abdominal surgery (14%), diabetes mellitus (13%), and human immunodeficiency virus infection (10%). In 47% of cases, species of Candida other than Candida albicans were isolated, most commonly Candida parapsilosis, Candida glabrata, and Candida tropicalis. Antifungal susceptibility testing of 394 isolates revealed minimal levels of azole resistance among C. albicans, C. tropicalis, and C. parapsilosis. These data document the substantial burden of candidemia and its changing epidemiology. Continued surveillance will be important to monitor the epidemiology of candidemia and to detect emergence of resistance to azoles.
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In the citing paper
“In population-based surveillance performed in the metropolitan areas of Atlanta, Georgia, and Baltimore, Maryland, candidemia incidence (primarily among adults) increased 10%–40% from the early 1990s and the late 2000s, which was followed by more recent reports of decreases in these areas (6,28–30).”
From Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016 (2019) · cites this paper as [29]
Experimental — accuracy not yet measuredIn the citing paper
“Antifungal drug susceptibility testing revealed minimal levels of azole resistance among bloodstream isolates of C. albicans, C. tropicalis, and C. parapsilosis (16).”
In the citing paper
“In a prospective population-based active surveillance conducted in Atlanta, Ga., and San Francisco, Calif., between 1992 and 1993, C. albicans was found to account for 52% of Candida BSI.”
In the citing paper
“Compared to the findings of an earlier population-based surveillance study in Atlanta and San Francisco (16), the overall incidence of candidemia was higher during this study.”
In the citing paper
“The incidence of disease in Connecticut (7 cases per 100,000 population) is similar to the incidence in Atlanta and San Francisco during 1992 and 1993 (8 cases per 100,000) (16) as well as to the incidence determined in a population-based study conducted in Iowa between 1998 and 2001 (6 cases per 100,000) (8).”
In the citing paper
“Other population-based and sentinel surveillance studies of nosocomial candidiasis, although not longitudinal in design, also showed that the proportion of fungemia due to C. albicans remained almost constant throughout the 1990s at about 50% and that the proportion due to Candida species other than C. albicans ranged from 42 to 48% (8, 9, 16, 26; reviewed in reference 23).”
In the citing paper
“Other population-based and sentinel surveillance studies of nosocomial candidiasis, although not longitudinal in design, also showed that the proportion of fungemia due to C. albicans remained almost constant throughout the 1990s at about 50% and that the proportion due to Candida species other than C. albicans ranged from 42 to 48% (8, 9, 16, 26; reviewed in reference 23).”
In the citing paper
“In a previous study (16), Kao et al. documented amphotericin B MICs ranging from 0.016 to 6 μg/ml, with 7% of isolates demonstrating potential resistance at concentrations of ≥2 μg/ml.”
In the citing paper
“Our susceptibility results for Candida species other than C. albicans mirror those of a study by Kao et al. (16) and the results of other studies (25, 37) in showing a low level of in vitro azole resistance in C. glabrata and C. tropicalis, no resistance in C. parapsilosis or the newly reported C. dubliniensis, and the expected high level of resistance in C. krusei.”
In the citing paper
“Our susceptibility results for Candida species other than C. albicans mirror those of a study by Kao et al. (16) and the results of other studies (25, 37) in showing a low level of in vitro azole resistance in C. glabrata and C. tropicalis, no resistance in C. parapsilosis or the newly reported C. dubliniensis, and the expected high level of resistance in C. krusei.”
In the citing paper
“Our susceptibility results for Candida species other than C. albicans mirror those of a study by Kao et al. (16) and the results of other studies (25, 37) in showing a low level of in vitro azole resistance in C. glabrata and C. tropicalis, no resistance in C. parapsilosis or the newly reported C. dubliniensis, and the expected high level of resistance in C. krusei.”
In the citing paper
“The decreased susceptibility of C. krusei to amphotericin B (MIC90, 2 μg/ml) is consistent with previous reports for this organism (16, 26).”
In the citing paper
“The high incidence of candidemia among infants, as well as the significant difference by race in this age group, was noted in the study of Kao et al. (16) and is known to be an important public health problem in this population (17, 35, 42).”
In the citing paper
“We confirmed the continuing predominance of C. albicans and C. parapsilosis in the neonatal population that Kao et al. (16) and Pfaller et al. (29) previously reported.”
In the citing paper
“Although antifungal prophylaxis with fluconazole has proven effective in preventing candidemia due to C. parapsilosis in the neonatal setting (117), a recent example of the emergence of fluconazole resistance in a strain endemic to a Finnish neonatal ICU underscores the importance of good infection control practices, rather than antifungal prophylaxis, in preventing infection with C. parapsilosis”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [117]
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Citations
Cites
National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.187 · Cited by 14,736
Manual of Clinical Microbiology.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-6-939_2 · Cited by 14,435
Journal of the National Medical Association
(2010) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30622-2 · Cited by 5,338
Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980-1990
Beck‐Sagué, C. M., Jarvis, W. R., & System, N. N. I. S. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.5.1247 · Cited by 1,140
Rex, J. H., Pfaller, M. A., Galgiani, J. N., Bartlett, M. S., Espinel-Ingroff, A., Ghannoum, M. A., Lancaster, M., Odds, F. C., Rinaldi, M. G., Walsh, T. J., et al. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.2.235 · Cited by 855
Self-citationEpidemiology of nosocomial fungal infections
Fridkin, S. K., & Jarvis, W. R. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.499 · Cited by 782
The Epidemiology of Hematogenous Candidiasis Caused by Different Candida Species
Abi‐Said, D., Anaissie, E., Uzun, O., Raad, I., Pinzcowski, H., & Vartivarian, S. (1997) · Clinical Infectious Diseases · doi:10.1086/513663 · Cited by 755
Nosocomial Candidiasis: Emerging Species, Reservoirs, and Modes of Transmission
Pfaller, M. A. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.supplement_2.s89 · Cited by 503
Self-citationInfectious Morbidity Associated with Long-Term Use of Venous Access Devices in Patients with Cancer
Groeger, J. S., Lucas, A. B., Thaler, H. T., Friedlander-Klar, H., Brown, A. E., Kiehn, T. E., & Armstrong, D. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-12-199312150-00003 · Cited by 426
Pfaller, M. A., Jones, R. N., Messer, S. A., Edmond, M. B., & Wenzel, R. P. (1998) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(97)00192-2 · Cited by 424
Self-citation
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Research works printed but not linked: 3
- Pittet, 1995, Archives of Internal Medicine, 155, 1177, 10.1001/archinte.1995.00430110089009 · DOI · Paper page
- 1993, MMWR. Morbidity and mortality weekly report, 42, 21
- 1992, MMWR. Morbidity and mortality weekly report, 41(SS-46), 25
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Self-citationColonização por Candida em indivíduos com candidemia
Miranda, L. D. N. (2008) · doi:10.11606/d.5.2008.tde-04042008-153349
Arthington, B. A., & Frade, J. P. (2010) · Issues in infectious diseases · doi:10.1159/000298761
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Kantarcıoğlu, A. S., & YÜCEL, A. (2014) · DergiPark (Istanbul University)
Whybrew, J. M. (2010) · Purdue e-Pubs (Purdue University System)
Hilbert, G. (2007) · Réanimation · doi:10.1016/s1624-0693(07)78766-2
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Valiengo, L. D. C. L., Petitto, C. E., Sawada, J. R., Fontes, R. B. V., & Pinto, F. C. G. (2007) · Revista de Medicina · doi:10.11606/issn.1679-9836.v86i2p112-116
Ogbolu, D. O., Alli, O. A. T., Adewumi, O. O., & Oluremi, A. S. (2015) · International Journal of TROPICAL DISEASE & Health · doi:10.9734/ijtdh/2015/16116
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Pimentel, S., Nona, J., Costa, T., & Valido, A. M. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.25754/pjp.2007.4656
Colombo, A. L., & Guimarães, T. (2003)
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Thompson, N. D. (2005) · OhioLink ETD Center (Ohio Library and Information Network)
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Bonfietti, L. X., & Melhem, M. D. S. C. (2011) · BEPA Boletim Epidemiológico Paulista
Oud, L. (2016) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2484w
This is to certify that the thesis/dissertation prepared
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da Costa, L., valiEngo, L., Petitto, C. E., Fontes, R. B. V., & Pinto, F. C. G. (2007)
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Bhattacharya, I., Bezawada, J., Yadav, J. S. S., Yan, S., Tyagi, R. D., & Surampalli, R. Y. (2016) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.2016.5.6.509-517
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Cota, J. M., Barnes, J. N., Frei, B. L., Frei, C. R., & Wiederhold, N. P. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007327
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Spellberg, B., Fu, Y., & Ibrahim, A. (2012) · ASM Press eBooks · doi:10.1128/9781555817176.ch12
Sule, H., Kumurya, A. S., & Ibrahim, A. (2020) · UMYU Journal of Microbiology Research (UJMR) · doi:10.47430/ujmr.2051.006
Hiddemann, W., Stemmler, H., Bausewein, C., Mück, M., & Schäffer, C. (2014)
Alarcón, A. E., & Bégué, R. E. (2019) · Springer eBooks · doi:10.1007/978-3-030-23311-2_23
Fukatsu, A., Tsuzukibashi, O., Fuchigami, M., Uchibori, S., Komine, C., Umezawa, K., Hayashi, S., Takahashi, Y., Kobayashi, T., Wakami, M., et al. (2022) · Open Journal of Stomatology · doi:10.4236/ojst.2022.124012
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Fungal infections in intensive therapy units
Barnes, R. A., & Backx, M. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755388.003.0036
Vickery, R. C. (2005) · Van Nostrand's Scientific Encyclopedia · doi:10.1002/0471743984.vse1416
Richardson, F. M. D., & Warnock, F. D. W. (2003) · Wiley eBooks · doi:10.1002/9780470755259.ch11
Hope, W. W. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13836.471336
Billé, J., Marchetti, O., Pittet, D., & Fungal Infection Network of Switzerland (FUNGINOS) (2004) · Clinical Infectious Diseases · doi:10.1086/422152
Jahanshahi, A., Nami, S., Feizi, A. A. H. P., Alihosseini, S., Jaberinezhad, M., Abdollahi, M., Rahimi, F., & Falahatian, M. (2023) · Clinical Case Reports · doi:10.1002/ccr3.7700
Hong, S. B. (2024) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2024.30.2.73
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Leite, G. G. V. R., & Damasceno, C. A. V. (2022) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000316
Pasqualotto, A. C. (2004) · Americanae (AECID Library)
Kılıç, A., & Palavecino, E. L. (2026) · Cureus · doi:10.7759/cureus.115734
Metadata
- Authors
- Kao, A. S., Brandt, M. E., Pruitt, W. R., Conn, L. A., Perkins, B. A., Stephens, D. S., Baughman, W. S., Reingold, A. L., Rothrock, G. A., Pfaller, M. A., Pinner, R. W., & Hajjeh, R. A.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Emory University (US)
- University of California, Berkeley (US)
- University of Iowa (US)
- Corresponding author
- Hajjeh, R. A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 29
- Issue
- 5
- Pages
- 1164-1170
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2162281126
- Cited by
- 457
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 1 · 2017: 9 · 2016: 13 · 2015: 14 · 2014: 21 · 2013: 19 · 2012: 19
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (SD-15/15-CID96-001)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- candidemia, Candida species, bloodstream infection, incidence, infants, antifungal susceptibility, azole resistance, Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, HIV infection, diabetes mellitus, cancer, abdominal surgery, Atlanta, San Francisco
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adolescent, Adult, Aged, Candidiasis, Child, Child, Preschool, Female, Georgia, Humans, Infant, Infant, Newborn, Male, Microbial Sensitivity Tests, Middle Aged, Prospective Studies, San Francisco, Incidence, Fungemia
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