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A Novel Surfactant Nanoemulsion with Broad‐Spectrum Sporicidal Activity against Bacillus Species
Abstract
Two nontoxic, antimicrobial nanoemulsions, BCTP and BCTP 401, have been developed. These emulsions are composed of detergents and oils in 80% water. BCTP diluted up to 1:1000 inactivated>90% of Bacillus anthracis spores in 4 h and was also sporicidal against three other Bacillus species. This sporicidal activity is due to disruption of the spore coat after initiation of germination without complete outgrowth. BCTP 401 diluted 1:1000 had greater activity than BCTP against Bacillus spores and had an onset of action of <30 min. Mixing BCTP or BCTP 401 with Bacillus cereus prior to subcutaneous injection in mice reduced the resulting skin lesion by 99%. Wound irrigation with BCTP 1 h after spore inoculation yielded a 98% reduction in skin lesion size, and mortality was reduced 3-fold. These nanoemulsion formulas are stable, easily dispersed, nonirritant, and nontoxic compared with other available sporicidal agents.
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Citations
Cited by
McClements, D. J., & Rao, J. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.559558 · Cited by 1,630
Nanoemulsion: Concepts, development and applications in drug delivery
Singh, Y., Meher, J. G., Raval, K., Khan, F. A., Chaurasia, M., Jain, N. K., & Chourasia, M. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.008 · Cited by 1,358
Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles—A brief study
Nirmala Grace, A., & Pandian, K. (2007) · Colloids and Surfaces A: Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2006.10.024 · Cited by 317
Hamouda, T., & Baker, J. R. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.01127.x · Cited by 277
Self-citationCurrent and Recent Advanced Strategies for Combating Biofilms
Sadekuzzaman, M., Yang, S., Mizan, M. F. R., & Ha, S. D. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12144 · Cited by 276
Metadata
- Authors
- Hamouda, T., Hayes, M. M., Cao, Z., Tonda, R., Johnson, K., Wright, D. C., Brisker, J., & Baker, J. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-12
- Volume
- 180
- Issue
- 6
- Pages
- 1939-1949
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2140350928
- Cited by
- 206
- References
- 0
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamouda, T., Hayes, M. M., Cao, Z., Tonda, R., Johnson, K., Wright, D. C., Brisker, J., & Baker, J. R. (1999). A Novel Surfactant Nanoemulsion with Broad‐Spectrum Sporicidal Activity against Bacillus Species. The Journal of Infectious Diseases. https://doi.org/10.1086/315124
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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