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Risk of Influenza A (H5N1) Infection among Health Care Workers Exposed to Patients with Influenza A (H5N1), Hong Kong
Abstract
The first outbreak of avian influenza A (H5N1) occurred among humans in Hong Kong in 1997. To estimate the risk of person-to-person transmission, a retrospective cohort study was conducted to compare the prevalence of H5N1 antibody among health care workers (HCWs) exposed to H5N1 case-patients with the prevalence among nonexposed HCWs. Information on H5N1 case-patient and poultry exposures and blood samples for H5N1-specific antibody testing were collected. Eight (3.7%) of 217 exposed and 2 (0.7%) of 309 nonexposed HCWs were H5N1 seropositive (P=.01). The difference remained significant after controlling for poultry exposure (P=.01). This study presents the first epidemiologic evidence that H5N1 viruses were transmitted from patients to HCWs. Human-to-human transmission of avian influenza may increase the chances for the emergence of a novel influenza virus with pandemic potential.
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Citations
Cited by
Avian Influenza A (H5N1) Infection in Humans
(2005) · New England Journal of Medicine · doi:10.1056/nejmra052211 · Cited by 1,285
Probable Person-to-Person Transmission of Avian Influenza A (H5N1)
Ungchusak, K., Auewarakul, P., Dowell, S. F., Kitphati, R., Auwanit, W., Puthavathana, P., Uiprasertkul, M., Boonnak, K., Pittayawonganon, C., Cox, N. J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044021 · Cited by 869
Self-citationKoopmans, M., Wilbrink, B., Conyn, M., Natrop, G., van der Nat, H., Vennema, H., Meijer, A., van Steenbergen, J., Fouchier, R., Osterhaus, A., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15589-x · Cited by 837
Influenza: lessons from past pandemics, warnings from current incidents
Horimoto, T., & Kawaoka, Y. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1208 · Cited by 696
The evolution of H5N1 influenza viruses in ducks in southern China
Chen, H., Deng, G., Li, Z., Tian, G., Li, Y., Jiao, P., Zhang, L., Liu, Z., Webster, R. G., & Yu, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403212101 · Cited by 536
Metadata
- Authors
- Bridges, C. B., Katz, J. M., Seto, W. H., Chan, P. K. S., Tsang, D., Ho, W., Mak, K. H., Lim, W., Tam, J. S., Clarke, M., Williams, S. G., Mounts, A. W., Bresee, J. S., Conn, L. A., Rowe, T., Hu‐Primmer, J., Abernathy, R. A., Lu, X., Cox, N. J., & Fukuda, K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 181
- Issue
- 1
- Pages
- 344-348
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2147306034
- Cited by
- 234
- References
- 0
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Risk of Influenza A (H5N1) Infection among Health Care Workers Exposed to Patients with Influenza A (H5N1), Hong Kong. https://app.cochat.ai/papers/10.1086/315213
- The paper
- Bridges, C. B., Katz, J. M., Seto, W. H., Chan, P. K. S., Tsang, D., Ho, W., Mak, K. H., Lim, W., Tam, J. S., Clarke, M., Williams, S. G., Mounts, A. W., Bresee, J. S., Conn, L. A., Rowe, T., Hu‐Primmer, J., Abernathy, R. A., Lu, X., Cox, N. J., & Fukuda, K. (2000). Risk of Influenza A (H5N1) Infection among Health Care Workers Exposed to Patients with Influenza A (H5N1), Hong Kong. The Journal of Infectious Diseases. https://doi.org/10.1086/315213
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
