The DOI matches its Crossref record.
Parasite Multiplication Potential and the Severity of Falciparum Malaria
Open accessAbstract
The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n=34) were compared with those from persons with severe malaria (n=42). To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to 1% parasitemia and used the same red blood cell donor. P. falciparum isolates from persons with severe malaria had initial cycle multiplication rates in vitro that were 3-fold higher than those from uncomplicated malaria (median [95% confidence interval], 8.3 [7. 1-10.5] vs. 2.8 [1.7-3.9]; P=.001). Parasites causing severe malaria exhibited unrestricted red blood cell invasion, whereas those from uncomplicated malaria were restricted to a geometric mean of 40 (31%-53%) of red blood cells. P. falciparum parasites causing severe malaria were less selective and multiplied more at high parasitemias than those causing uncomplicated malaria.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,746
Asymptomatic malaria infections: detectability, transmissibility and public health relevance
Bousema, T., Okell, L., Felger, I., & Drakeley, C. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3364 · Cited by 696
Imperfect vaccines and the evolution of pathogen virulence
Gandon, S., Mackinnon, M. J., Nee, S., & Read, A. F. (2001) · Nature · doi:10.1038/414751a · Cited by 630
The pathophysiology of vivax malaria
Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.02.003 · Cited by 428
White, N. J. (2017) · Malaria Journal · doi:10.1186/s12936-017-1731-1 · Cited by 230
Self-citation
Metadata
- Authors
- Chotivanich, K., Udomsangpetch, R., Simpson, J. A., Newton, P., Pukrittayakamee, S., Looareesuwan, S., & White, N. J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 181
- Issue
- 3
- Pages
- 1206-1209
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2171479498
- Cited by
- 191
- References
- 0
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Parasite Multiplication Potential and the Severity of Falciparum Malaria. https://app.cochat.ai/papers/10.1086/315353
- The paper
- Chotivanich, K., Udomsangpetch, R., Simpson, J. A., Newton, P., Pukrittayakamee, S., Looareesuwan, S., & White, N. J. (2000). Parasite Multiplication Potential and the Severity of Falciparum Malaria. The Journal of Infectious Diseases. https://doi.org/10.1086/315353
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
