The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Persistent Diarrhea Signals a Critical Period of Increased Diarrhea Burdens and Nutritional Shortfalls: A Prospective Cohort Study among Children in Northeastern Brazil
Abstract
Persistent diarrhea (PD; duration >/=14 days) is a growing part of the global burden of diarrheal diseases. A 45-month prospective cohort study (with illness, nutritional, and microbiologic surveillance) was conducted in a shantytown in northeastern Brazil, to elucidate the epidemiology, nutritional impact, and causes of PD in early childhood (0-3 years of age). A nested case-control design was used to examine children's diarrhea burden and nutritional status before and after a first PD illness. PD illnesses accounted for 8% of episodes and 34% of days of diarrhea. First PD illnesses were preceded by a doubling of acute diarrhea burdens, were followed by further 2.6-3.5-fold increased diarrhea burdens for 18 months, and were associated with acute weight shortfalls. Exclusively breast-fed children had 8-fold lower diarrhea rates than did weaned children. PD-associated etiologic agents included Cryptosporidium, Giardia, enteric adenoviruses, and enterotoxigenic Escherichia coli. PD signals growth shortfalls and increased diarrhea burdens; children with PD merit extended support, and the illness warrants further study to elucidate its prevention, treatment, and impact.
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Citations
Cites
Mortality by cause for eight regions of the world: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07493-4 · Cited by 4,043 · cited 2×
“The 1997 report by Murray and Lopez on disability-adjusted life years (DALYs) for specific diseases notes that the 3 leading causes of global DALYs are, in descending order, lower respiratory infections, diarrheal diseases, and perinatal disorders [1, 2].”
Background
Cited by
The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease
Guerrant, R. L., DeBoer, M. D., Moore, S. R., Scharf, R. J., & Lima, A. A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.239 · Cited by 604
Updating the DALYs for diarrhoeal disease
Guerrant, R. L., Kosek, M., Lima, A. A. M., Lorntz, B., & Guyatt, H. L. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(02)02253-5 · Cited by 126
Self-citationFactors associated with stunting in healthy children aged 5 years and less living in Bangui (RCA)
Vonaesch, P., Tondeur, L., Breurec, S., Bata, P., Nguyen, L. B. L., Frank, T., Farra, A., Rafaï, C., Giles-Vernick, T., Gody, J. C., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182363 · Cited by 103
Metadata
- Authors
- Lima, A. A. M., Moore, S. R., Barboza, Jr., Soares, A. M., Schleupner, M. A., Newman, R. D., Sears, C. L., Nataro, J. P., Fedorko, D. P., Wuhib, T., Schorling, J. B., & Guerrant, R. L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-05
- Volume
- 181
- Issue
- 5
- Pages
- 1643-1651
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2109428580
- Cited by
- 258
- References
- 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Persistent Diarrhea Signals a Critical Period of Increased Diarrhea Burdens and Nutritional Shortfalls: A Prospective Cohort Study among Children in Northeastern Brazil. https://app.cochat.ai/papers/10.1086/315423
- The paper
- Lima, A. A. M., Moore, S. R., Barboza, Jr., Soares, A. M., Schleupner, M. A., Newman, R. D., Sears, C. L., Nataro, J. P., Fedorko, D. P., Wuhib, T., Schorling, J. B., & Guerrant, R. L. (2000). Persistent Diarrhea Signals a Critical Period of Increased Diarrhea Burdens and Nutritional Shortfalls: A Prospective Cohort Study among Children in Northeastern Brazil. The Journal of Infectious Diseases. https://doi.org/10.1086/315423
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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