The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biology and Molecular Epidemiology of Diphtheria Toxin and the tox Gene
Abstract
Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in some corynephages, and DT is only produced by C. diphtheriae isolates that harbor tox+ phages. The diphtheria toxin repressor (DtxR) is a global regulatory protein that uses Fe2+ as co-repressor. Holo-DtxR represses production of DT, corynebacterial siderophore, heme oxygenase, and several other proteins. Diagnostic tests for toxinogenicity of C. diphtheriae are based either on immunoassays or on bioassays for DT. Molecular analysis of tox and dtxR genes in recent clinical isolates of C. diphtheriae revealed several tox alleles that encode identical DT proteins and multiple dtxR alleles that encode five variants of DtxR protein. Therefore, recent clinical isolates of C. diphtheriae produce a single antigenic type of DT, and diphtheria toxoid continues to be an effective vaccine for immunization against diphtheria.
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Citations
Cites
Regulation of ferric iron transport in Escherichia coli K12: Isolation of a constitutive mutant
Hantke, K. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00269672 · Cited by 563
Schmitt, M. P. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.3.838-845.1997 · Cited by 234
Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex
White, A., Ding, X., vanderSpek, J. C., Murphy, J. R., & Ringe, D. (1998) · Nature · doi:10.1038/28893 · Cited by 180
Cited by
Pohl, E., Haller, J. C., Mijovilovich, A., Meyer‐Klaucke, W., Garman, E., & Vasil, M. L. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03337.x · Cited by 326
Recognition of DNA by Fur: a Reinterpretation of the Fur Box Consensus Sequence
Baichoo, N., & Helmann, J. D. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.5826-5832.2002 · Cited by 282
Recent developments in understanding the iron acquisition strategies of gram positive pathogens
Sheldon, J. R., & Heinrichs, D. E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv009 · Cited by 272
Out of the iron age: new insights into the critical role of manganese homeostasis in bacteria
Jakubovics, N. S., & Jenkinson, H. F. (2001) · Microbiology · doi:10.1099/00221287-147-7-1709 · Cited by 267
Kunkle, C. A., & Schmitt, M. P. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.23.6826-6840.2003 · Cited by 71
Metadata
- Authors
- Holmes, R. K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02
- Volume
- 181
- Issue
- s1
- Pages
- S156-S167
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1967073350
- Cited by
- 234
- References
- 3
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
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