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Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Community-Acquired Lower Respiratory Tract Infections

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Principi, N., Esposito, S., Blasi, F., Allegra, L., the Mowgli Study Group·2001·Clinical Infectious Diseases

Abstract

In order to evaluate the role of Mycoplasma pneumoniae and Chlamydia pneumoniae, we studied 613 children aged 2-14 years who were hospitalized for community-acquired lower respiratory tract infections (LRTIs). The patients were enrolled in the study by 21 centers in different regions of Italy from May 1998 through April 1999. Paired serum samples were obtained on admission and after 4-6 weeks to assay the titers of M. pneumoniae and C. pneumoniae antibodies. Nasopharyngeal aspirates for the detection of M. pneumoniae and C. pneumoniae were obtained on admission. Acute M. pneumoniae infections in 210 patients (34.3%) and acute C. pneumoniae infections in 87 (14.1%) were diagnosed. Fifteen of the 18 children with M. pneumoniae and/or C. pneumoniae infections whose treatments were considered clinical failures 4-6 weeks after enrollment had not been treated with macrolides. Our study confirms that M. pneumoniae and/or C. pneumoniae plays a significant role in community-acquired LRTIs in children of all ages and that such infections have a more complicated course when not treated with adequate antimicrobial agents.

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Metadata

Authors
Principi, N., Esposito, S., Blasi, F., Allegra, L., & the Mowgli Study Group
Venue
Clinical Infectious Diseases
Published
2001-05-01
Volume
32
Issue
9
Pages
1281-1289
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2128177294
Cited by
266
References
1
FWCI
11.08
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Community-Acquired Lower Respiratory Tract Infections. https://app.cochat.ai/papers/10.1086/319981
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Principi, N., Esposito, S., Blasi, F., Allegra, L., & the Mowgli Study Group. (2001). Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Community-Acquired Lower Respiratory Tract Infections. Clinical Infectious Diseases. https://doi.org/10.1086/319981

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