Prevalence of Vaginal Colonization by Drug‐Resistant Candida Species in College‐Age Women with Previous Exposure to Over‐the‐Counter Azole Antifungals
Abstract
We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.
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Clinical resistance of C. albicans to antifungal agents remains rare.
“Although clinical resistance to antifungal agents remains rare, overexposure to azoles may increase the development of fluconazole-resistant C. albicans strains.”
From Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion (2022) · cites this paper as Mathema et al., 2001
Overexposure to azoles may increase the development of fluconazole-resistant C. albicans strains.
“Although clinical resistance to antifungal agents remains rare, overexposure to azoles may increase the development of fluconazole-resistant C. albicans strains.”
From Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion (2022) · cites this paper as Mathema et al., 2001
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References 30 · Cited by 65
- Authors
- Mathema, B., Cross, E., Dun, E., Park, S., Bedell, J., Slade, B., Williams, M., Riley, L., Chaturvedi, V., & Perlin, D. S.
- Affiliations
- Columbia University (US)
- Cornell University (US)
- University of California, Berkeley (US)
- New York State Department of Health (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09
- Volume
- 33
- Issue
- 5
- Pages
- e23-e27
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2073104265
- Cited by
- 65
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- vaginal colonization, azole antifungals, candidiasis, college-age women, vaginal microbiota, antifungal resistance
- MeSH terms
- Adult, Antifungal Agents, Azoles, Candidiasis, Vulvovaginal, Cross-Sectional Studies, Drug Resistance, Microbial, Nonprescription Drugs, Female, Humans, Middle Aged, Students, United States, Fluconazole, Prevalence
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