Acute Ethanol Intoxication Suppresses Lung Chemokine Production following Infection with Streptococcus pneumoniae
Abstract
Alcohol intoxication impairs neutrophil function and increases host susceptibility to Streptococcus pneumoniae. In a rat model of pneumonia, the effects of acute intoxication were monitored for lung chemokine responses, neutrophil recruitment, and bactericidal activity. Alcohol delayed lung neutrophil recruitment, increased bacterial burden, and decreased survival. Before neutrophil recruitment, bronchoalveolar lavage (BAL) macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (CINC) were decreased by alcohol. This alcohol-induced effect was reversed at 6 h, when there were large numbers of neutrophils in control BAL fluid, compared with the alcohol-treated group. Cyclophosphamide-induced neutropenia decreased neutrophil recruitment, minimizing the effects of recruited neutrophils on chemokine levels, and extended the alcohol-induced chemokine suppression. MIP-2 and CINC mRNA contents also were suppressed by alcohol 4 and 6 h after infection. Thus, alcohol suppresses lung chemokine activity in response to S. pneumoniae, which is associated with delayed neutrophil delivery, elevated bacterial burden, and increased mortality.
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Alcohol exposure has a suppressive effect on the release of cytokines responsible for cell signalling and critical for regulation of host defence.
“Alcohol exposure has a suppressive effect on the release of cytokines responsible for cell signalling and critical for regulation of the host defence 80, 81.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [81]
Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, especially with heavy drinking and alcohol use disorders.
“Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, and especially with heavy drinking and alcohol use disorders 79, 80, 81, 214, 215, 216, 217.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [81]
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References 33 · Cited by 111
- Authors
- Boé, D. M., Nelson, S., Zhang, P., & Bagby, G. J.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Corresponding author
- Boé, Darren M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11
- Volume
- 184
- Issue
- 9
- Pages
- 1134-1142
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2150631988
- Cited by
- 111
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 1 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA-09903)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- acute ethanol intoxication, Streptococcus pneumoniae, pneumonia, neutrophil recruitment, CXCL2, cytokine-induced neutrophil chemoattractant, cyclophosphamide-induced neutropenia, bacterial load, alcohol-induced immunosuppression, host susceptibility to infection
- MeSH terms
- Ethanol, Alcoholic Intoxication, Animals, Bronchoalveolar Lavage Fluid, Chemotactic Factors, Cyclophosphamide, Disease Models, Animal, Growth Substances, Humans, Lung, Neutropenia, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Rats, Sprague-Dawley, Chemokines, Chemokines, CXC, Neutrophil Infiltration, Intercellular Signaling Peptides and Proteins, Rats, Chemokine CXCL1, Chemokine CXCL2
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