The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q
Open accessAbstract
Restless legs syndrome (RLS) is a neurological disorder characterized by leg paresthesia associated with an irresistible urge to move that often interferes with nocturnal sleep, leading to chronic sleep deprivation. To map genes that may play a role in the vulnerability to RLS, a genomewide scan was conducted in a large French-Canadian family. Significant linkage was established on chromosome 12q, for a series of adjacent microsatellite markers with a maximum two-point LOD score of 3.42 (recombination fraction.05; P=6x10(-4); autosomal recessive mode of inheritance), whereas multipoint linkage calculations yielded a LOD score of 3.59. Haplotype analysis refined the genetic interval, positioning the RLS-predisposing gene in a 14.71-cM region between D12S1044 and D12S78. These findings represent the first mapping of a locus conferring susceptibility to RLS.
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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,682
Principles and Practice of Sleep Medicine
(2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,088
Strategies for multilocus linkage analysis in humans.
Lathrop, G. M., Lalouel, J. M., Julier, C., & Ott, J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.11.3443 · Cited by 2,559
Faster sequential genetic linkage computations.
Cottingham, R. W., Idury, R. M., & Schäffer, A. A. (1993) · Europe PMC (PubMed Central) · Cited by 1,364
Sobel, E. M., & Lange, K. L. (1996) · PubMed Central · Cited by 1,176
Toward a better definition of the restless legs syndrome
Walters, A. S., Aldrich, M. S., Allen, R., Ancoli‐Israel, S., Buchholz, D., Chokroverty, S., Coccagna, G., Earley, C., Ehrenberg, B., Feest, T. G., et al. (1995) · Movement Disorders · doi:10.1002/mds.870100517 · Cited by 1,101
Self-citationMontplaisir, J., Boucher, S., Poirier, G., Lavigne, G., Lapierre, O., & Lespérance, P. (1997) · Movement Disorders · doi:10.1002/mds.870120111 · Cited by 937
Self-citationEkbom, K. A. (1960) · Neurology · doi:10.1212/wnl.10.9.868 · Cited by 841
Epidemiology of Restless Legs Symptoms in Adults
Phillips, B., Young, T., Finn, L., Asher, K., Hening, W. A., & Purvis, C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2137 · Cited by 769
Cited by
Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology
Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, C., Walters, A. S., & Montplaisi, J. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00010-8 · Cited by 2,900
Restless legs syndrome: Revisiting the dopamine hypothesis from the spinal cord perspective
Clemens, S., Rye, D., & Hochman, S. (2006) · Neurology · doi:10.1212/01.wnl.0000223316.53428.c9 · Cited by 465
Evidence for a genetic association between monoamine oxidase A and restless legs syndrome
Desautels, A., Turecki, G., Montplaisir, J., Brisebois, K., Sequeira, A., Adam, B., & Rouleau, G. A. (2002) · Neurology · doi:10.1212/wnl.59.2.215 · Cited by 100
Self-citation(2006) · Cited by 58
Mason, T. B. A., & Pack, A. I. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.06.042 · Cited by 52
Metadata
- Authors
- Desautels, A., Turecki, G., Montplaisir, J., Sequeira, A., Verner, A., & Rouleau, G. A.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 69
- Issue
- 6
- Pages
- 1266-1270
- ISSN
- 0002-9297 (ISSN-L)
- OpenAlex
- W1979385900
- Cited by
- 273
- References
- 35
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Desautels, A., Turecki, G., Montplaisir, J., Sequeira, A., Verner, A., & Rouleau, G. A. (2001). Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q. The American Journal of Human Genetics. https://doi.org/10.1086/324649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
