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Escherichia coli Harboring Shiga Toxin 2 Gene Variants: Frequency and Association with Clinical Symptoms
Abstract
Shiga toxin (Stx)-producing Escherichia coli (STEC) from patients with hemolytic-uremic syndrome (HUS), patients with diarrhea without HUS, or asymptomatic subjects were genotyped to assess associations between stx2 variants and clinical manifestations of infection. Neither stx2d nor stx2e was found in 268 STEC isolates from patients with HUS. Of 262 STEC isolates from patients with diarrhea, stx(2d) was found in 41 (15.6%; P<.000001), and stx2e was found in 12 (4.6%; P=.0004). The stx2c genotype frequency was similar among isolates from patients with HUS (3.7%) and diarrhea (5.0%). The frequencies of stx2c, stx2d, and stx2e among 96 STEC isolates from asymptomatic subjects were comparable to those among isolates from patients with diarrhea. None of the 626 STEC isolates contained stx2f. All stx2d-positive or stx2e-positive STEC isolates were eae negative and originated from subjects older than those with STEC isolates with stx2c. stx2c-positive STEC isolates can cause HUS, but the presence of stx2d or stx2e may predict a milder disease with a minimal risk of HUS.
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Cited by
Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany
Frank, C., Werber, D., Cramer, J. P., Askar, M., Faber, M., an der Heiden, M., Bernard, H., Fruth, A., Prager, R., Spode, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106483 · Cited by 1,139
Shiga toxin-producing Escherichia coli: An overview1
Gyles, C. L. (2007) · Journal of Animal Science · doi:10.2527/jas.2006-508 · Cited by 849
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Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
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Caprioli, A., Morabito, S., Brug�re, H., & Oswald, E. (2005) · Veterinary Research · doi:10.1051/vetres:2005002 · Cited by 668
Kim, M. J., Kim, S. H., Kim, T. S., Kee, H.-Y., Seo, J.-J., Kim, E.-S., Park, J.-T., Chung, J. K., & Lee, J. (2009) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2009.39.1.29 · Cited by 7
Metadata
- Authors
- Friedrich, A. W., Bielaszewska, M., Zhang, W., Pulz, M., Kuczius, T., Ammon, A., & Karch, H.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01
- Volume
- 185
- Issue
- 1
- Pages
- 74-84
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2152964535
- Cited by
- 730
- References
- 0
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Friedrich, A. W., Bielaszewska, M., Zhang, W., Pulz, M., Kuczius, T., Ammon, A., & Karch, H. (2002). Escherichia coli Harboring Shiga Toxin 2 Gene Variants: Frequency and Association with Clinical Symptoms. The Journal of Infectious Diseases. https://doi.org/10.1086/338115
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