The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus–Infected Persons in Clinical Trials
Abstract
We prospectively studied long-term antiretroviral adherence patterns and their impact on biologic outcomes for human immunodeficiency virus (HIV)-infected participants in 2 randomized, multicenter clinical trials. For the period from baseline to month 12 of the study, participants who reported adherence levels of 100%, 80%-99%, and 0%-79% had plasma HIV RNA levels that decreased by 2.77, 2.33, and 0.67 log(10) copies/mL, respectively (P<.001), whereas their CD4 counts increased by 179, 159, and 53 cells/mm(3), respectively (P<.001). Adherence predicted nondetectable HIV RNA levels (<50 copies/mL) at 12 months of follow-up (P<.001). The HIV RNA level was nondetectable in 72% of participants who reported 100% adherence at all 4 follow-up visits, compared with 66%, 41%, 35%, and 13% of participants who reported 100% adherence at 3, 2, 1, or 0 follow-up visits, respectively (P<.001). Nonwhite race was associated with poorer adherence (P<.001), and older age was associated with better adherence (P<.001).
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Cites
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
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Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., & PATIENT CARE COMMITTEE & ADHERENCE (2000) · AIDS Care · doi:10.1080/09540120050042891 · Cited by 1,428 · cited 1×
“CPCRA self-report consisted of a global 7-day recall rather than a day-by-day 3- or 4-day recall, as used in many other studies [42].”
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Self-citationHow often is medication taken as prescribed? A novel assessment technique
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(2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-3-200202050-00020 · Cited by 502
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Cited by
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244
Impact of HIV‐related stigma on treatment adherence: systematic review and meta‐synthesis
Katz, I. T., Ryu, A. E., Onuegbu, A. G., Psaros, C., Weiser, S. D., Bangsberg, D. R., & Tsai, A. C. (2013) · Journal of the International AIDS Society · doi:10.7448/ias.16.3.18640 · Cited by 1,126
Shippee, N. D., Shah, N. D., May, C. R., Mair, F. S., & Montori, V. M. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.05.005 · Cited by 728
Grenard, J. L., Munjas, B. A., Adams, J. L., Suttorp, M., Maglione, M., McGlynn, E. A., & Gellad, W. F. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1704-y · Cited by 635
Metadata
- Authors
- Mannheimer, S., Friedland, G., Matts, J., Child, C., Chesney, M., & Terry Beirn Community Programs for Clinical Research on, A. I. D. S.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04-15
- Volume
- 34
- Issue
- 8
- Pages
- 1115-1121
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2166670196
- Cited by
- 512
- References
- 25
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mannheimer, S., Friedland, G., Matts, J., Child, C., Chesney, M., & Terry Beirn Community Programs for Clinical Research on, A. I. D. S. (2002). The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus–Infected Persons in Clinical Trials. Clinical Infectious Diseases. https://doi.org/10.1086/339074
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
