The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Effect of Age on Immunologic Response to Recombinant Hepatitis B Vaccine: A Meta‐analysis
Abstract
Hepatitis B vaccine is a key tool for the prevention of hepatitis B infection. Age-associated changes in immune function may contribute to decreased vaccine efficacy in older individuals, although research related to this topic has yielded contradictory findings. We performed a meta-analysis of 24 published trials and studies that evaluated the association of age with response to hepatitis B vaccine, using a random-effects model. Pooling of study results suggested a significantly increased risk of nonresponse to hepatitis B vaccine among older individuals (relative risk [RR], 1.76; 95% confidence interval [CI], 1.48-2.10). An elevated risk of nonresponse persisted even after exclusion of poor-quality studies (RR, 1.63; 95% CI, 1.23-2.15) and adjustment for publication bias (RR, 1.52; 95% CI, 1.26-1.83), and it was present even when "older" individuals were defined as being as young as 30 years. These findings have important implications for individuals at risk for hepatitis B infection, including health care workers and travelers.
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Meta-analysis: Principles and procedures
Egger, M., Smith, G. D., & Phillips, A. N. (1997) · BMJ · doi:10.1136/bmj.315.7121.1533 · Cited by 2,415
Cited by
Hakim, F. T., Flomerfelt, F. A., Boyiadzis, M., & Gress, R. E. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.01.009 · Cited by 272
Prevention of Hepatitis B with the Hepatitis B Vaccine
Poland, G. A., & Jacobson, R. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmcp041507 · Cited by 268
Jackson, S., Lentino, J., Kopp, J., Murray, L., Ellison, W., Rhee, M., Shockey, G., Akella, L., Erby, K., Heyward, W. L., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2017.12.038 · Cited by 197
Petäjä, T., Pedersen, C., Poder, A., Strauss, G., Catteau, G., Thomas, F., Lehtinen, M., & Descamps, D. (2011) · International Journal of Cancer · doi:10.1002/ijc.25887 · Cited by 91
Leonardi, S., Spina, M., Spicuzza, L., Rotolo, N., & La Rosa, M. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.07.099 · Cited by 67
Metadata
- Authors
- Fisman, D. N., Agrawal, D., & Leder, K.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 35
- Issue
- 11
- Pages
- 1368-1375
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2144641242
- Cited by
- 214
- References
- 1
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fisman, D. N., Agrawal, D., & Leder, K. (2002). The Effect of Age on Immunologic Response to Recombinant Hepatitis B Vaccine: A Meta‐analysis. Clinical Infectious Diseases. https://doi.org/10.1086/344271
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
