The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ethnic‐Specific Genetic Associations with Pulmonary Tuberculosis
Abstract
Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here, polymorphisms in the natural resistance-associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-10 genes were evaluated in 358 Cambodian patients with pulmonary TB and 106 tuberculin-positive control subjects. Heterozygosity for the -1082 polymorphism of the IL-10 promoter and heterozygosity for 2 linked polymorphic NRAMP1 variants, D543N and 3' untranslated region, were associated with TB susceptibility and resistance, respectively. Other polymorphisms associated with differential susceptibility to TB were not associated with susceptibility or resistance to TB in Cambodians. The novel pattern of genetic associations with susceptibility and resistance to TB detected in Cambodia is consistent with the conclusion that unique environmental and natural selective factors have resulted in the development of ethnic-specific host genetic factors associated with TB susceptibility and resistance worldwide.
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Cites
Wilkinson, R. J., Patel, P., Llewelyn, M., Hirsch, C. S., Pasvol, G., Snounou, G., Davidson, R. N., & Toossi, Z. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1863 · Cited by 295
Consequence of Nramp1 Deletion to Mycobacterium tuberculosis Infection in Mice
North, R. J., LaCourse, R., Ryan, L., & Gros, P. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5811-5814.1999 · Cited by 76
Cited by
Frieden, T. R., Sterling, T. R., Munsiff, S. S., Watt, C. J., & Dye, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14333-4 · Cited by 689
Li, X., Yang, Y., Zhou, F., Zhang, Y., Lu, H., Jin, Q., & Gao, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015831 · Cited by 126
NRAMP1 D543N and INT4 polymorphisms in susceptibility to pulmonary tuberculosis: A meta-analysis
Yuan, L., Ke, Z., Guo, Y., Xi, X., & Luo, Z. (2017) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2017.06.022 · Cited by 17
Metadata
- Authors
- Delgado, J. C., Baena, A., Thim, S., & Goldfeld, A. E.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-15
- Volume
- 186
- Issue
- 10
- Pages
- 1463-1468
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2145788769
- Cited by
- 261
- References
- 2
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Delgado, J. C., Baena, A., Thim, S., & Goldfeld, A. E. (2002). Ethnic‐Specific Genetic Associations with Pulmonary Tuberculosis. The Journal of Infectious Diseases. https://doi.org/10.1086/344891
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