The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Severe Staphylococcus aureus Infections Caused by Clonally Related Community-Acquired Methicillin-Susceptible and Methicillin-Resistant Isolates
Abstract
We investigated the genetic relatedness of 5 community-acquired (CA) Staphylococcus aureus isolates obtained from 4 consecutive pediatric patients presenting with sepsis syndrome and severe pneumonia during a 3-week period in 2000. Two patients were infected with methicillin-susceptible S. aureus (MSSA), and 2 were infected with methicillin-resistant S. aureus (MRSA). The pulsed-field gel electrophoresis patterns for the 2 CA-MRSA isolates were identical to each other, as were the patterns for the 3 CA-MSSA isolates. A 2-band difference reflecting the presence of a staphylococcal cassette chromosome mec (SCCmec) element distinguished the CA-MRSA isolates from the CA-MSSA isolates. The small, mobile type IV SCCmec element was present in the CA-MRSA isolates. These data suggest that an insertion or, less likely, a deletion of the SCCmec type IV element occurred in a highly virulent S. aureus background. Staphylococcal toxin genes sea, seh, lukS-PV, and lukF-PV were detected in all isolates. Also, in all isolates, was a partial homolog of seo (seo'). The relationship among these patient isolates strengthens the assumption that CA-MRSA infections may be caused by isolates closely related to MSSA isolates.
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Cited by
Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Self-citationMiller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat
Zetola, N., Francis, J. S., Nuermberger, E. L., & Bishai, W. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70112-2 · Cited by 791
Francis, J. S., Doherty, M. C., Lopatin, U., Johnston, C. P., Sinha, G., Ross, T., Cai, M., Hansel, N. N., Perl, T., Ticehurst, J. R., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/427148 · Cited by 719
Metadata
- Authors
- Mongkolrattanothai, K., Boyle, S., Kahana, M. D., & Daum, R. S.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-15
- Volume
- 37
- Issue
- 8
- Pages
- 1050-1058
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2156396250
- Cited by
- 230
- References
- 3
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mongkolrattanothai, K., Boyle, S., Kahana, M. D., & Daum, R. S. (2003). Severe Staphylococcus aureus Infections Caused by Clonally Related Community-Acquired Methicillin-Susceptible and Methicillin-Resistant Isolates. Clinical Infectious Diseases. https://doi.org/10.1086/378277
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