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The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax
Open accessAbstract
Red blood cells (RBCs) must deform considerably during their multiple passages through the microvasculature and the sinusoids of the spleen. RBCs infected with Plasmodium falciparum (Pf-IRBCs) become increasingly rigid as they mature but avoid splenic clearance by sequestering in venules and capillaries. In contrast, RBCs infected with P. vivax (Pv-IRBCs) do not sequester. We compared the effects of P. vivax and P. falciparum infection on RBC deformability in a laminar shear flow system. Pf-IRBCs became more rigid as the parasite matured, but equivalent maturation of Pv-IRBCs resulted in a doubling of flexibility. Coincidentally, the IRBC surface area increased from 56.7+/-1.3 microm2 to 74.7+/-0.6 microm2 to 90.9+/-1.1 microm2 in ring-, trophozoite-, and schizont-stage Pv-IRBCs, respectively, whereas Pf-IRBCs did not increase in size. P. vivax increases the deformability of IRBCs and thereby avoids splenic entrapment.
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Cited by
White, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
Self-citationComparative genomics of the neglected human malaria parasite Plasmodium vivax
Carlton, J. M., Adams, J. H., Silva, J. C., Bidwell, S. L., Lorenzi, H., Caler, E., Crabtree, J., Angiuoli, S. V., Merino, E. F., Amedeo, P., et al. (2008) · Nature · doi:10.1038/nature07327 · Cited by 835
Bousema, T., & Drakeley, C. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-10 · Cited by 746
Biomechanics approaches to studying human diseases
Lee, G. Y. H., & Lim, C. T. (2007) · Trends in Biotechnology · doi:10.1016/j.tibtech.2007.01.005 · Cited by 485
The pathophysiology of vivax malaria
Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.02.003 · Cited by 428
Metadata
- Authors
- Suwanarusk, R., Cooke, B. M., Dondorp, A. M., Silamut, K., Sattabongkot, J., White, N. J., & Udomsangpetch, R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-15
- Volume
- 189
- Issue
- 2
- Pages
- 190-194
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2152850883
- Cited by
- 187
- References
- 0
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Suwanarusk, R., Cooke, B. M., Dondorp, A. M., Silamut, K., Sattabongkot, J., White, N. J., & Udomsangpetch, R. (2004). The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax. The Journal of Infectious Diseases. https://doi.org/10.1086/380468
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