Dissection of Genomewide-Scan Data in Extended Families Reveals a Major Locus and Oligogenic Susceptibility for Age-Related Macular Degeneration

Iyengar, Sudha K., Song, Danhong, Klein, Barbara E.K., Klein, Ronald, Schick, James H., Humphrey, Jennifer, Millard, Christopher, Liptak, Rachel, Russo, Karlie, Jun, Gyungah, Lee, Kristine E., Fijal, Bonnie, Elston, Robert C.·2004·The American Journal of Human Genetics

Cited by (173)

Items 101–173 of 173

  1. Epidemiology of Age-related Macular Degeneration
    Johanna M. Seddon, Lucia Sobrin · 2008 · Elsevier eBooks
  2. Y402H-Polymorphismus im Komplementfaktor H und altersabhängige Makuladegeneration (AMD)
    Hendrik P. N. Scholl, Bernhard H. F. Weber, Markus Maria Nöthen, T. F. Wienker, Frank Gerhard Holz · 2005 · Der Ophthalmologe
  3. Further Support for the Common Variants in Complement Factor H (Y402H) and LOC387715 (A69S) Genes as Major Risk Factors for the Exudative Age-Related Macular Degeneration
    Barkur S. Shastry · 2006 · Ophthalmologica
  4. Hemicentin 1 influences podocyte dynamic changes in glomerular diseases
    Barbara Toffoli, Cristina Zennaro, Carine Winkler, Greta Maria Paola Giordano Attianese, Stella Bernardi, Michele Carraro, Federica Gilardi, Béatrice Desvergne · 2018 · American Journal of Physiology-Renal Physiology
  5. Expanded Genome Scan in Extended Families with Age-Related Macular Degeneration
    Sandra Barral, Peter James Francis, Dennis W. Schultz, Mitchell B. Schain, Chad A. Haynes, Jacek Majewski, Jürg Ott, Ted S. Acott, Richard G. Weleber, Michael L. Klein · 2006 · Investigative Ophthalmology & Visual Science
  6. An Intergenic Region between the tagSNP rs3793917 and rs11200638 in the HTRA1 Gene Indicates Association with Age-Related Macular Degeneration
    Andrea Jane Richardson, Amirul F. M. Islam, Khin Zaw Aung, Robyn H. Guymer, Paul Nigel Baird · 2010 · Investigative Ophthalmology & Visual Science
  7. A Discordant Sib-Pair Linkage Analysis of Age-Related Macular Degeneration
    Susan L. Santangelo, Chen-Hsing Yen, Stephen A. Haddad, Jesen A. Fagerness, Christine Huang, Johanna M. Seddon · 2005 · Ophthalmic Genetics
  8. Genetics of Pigment Changes and Geographic Atrophy
    Cheryl L. Thompson, Gyungah Jun, Ronald Klein, Ronald Klein, Jennifer Capriotti, Kristine E. Lee, Sudha K. Iyengar · 2007 · Investigative Ophthalmology & Visual Science
  9. Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration.
    Christine M. Bojanowski, Jingsheng Tuo, Emily Y. Chew, Karl G. Csaky, Chi‐Chao Chan · 2005 · Europe PMC (PubMed Central)
  10. Clinical applications of whole-genome association studies: future applications at the bedside
    Alison A. Motsinger‐Reif, Marylyn DeRiggi Ritchie, Seth E Dobrin · 2006 · Expert Review of Molecular Diagnostics
  11. CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients
    Fernando Cruz-González, Clara Cieza-Borrella, Gloria López Valverde, R. Lorenzo-Pérez, Emiliano Hernández-Galilea, Rogelio González‐Sarmiento · 2013 · Ophthalmic Genetics
  12. 10q26 – The enigma in age-related macular degeneration
    David Adrian Merle, Merve Sen, Angela Armento, Chloë M. Stanton, Eric F. Thee, Magda A. Meester‐Smoor, Markus Kaiser, Simon J. Clark, Caroline C. W. Klaver, Pearse Andrew Keane et al. · 2022 · Progress in Retinal and Eye Research
  13. Whole exome sequencing of extreme age-related macular degeneration phenotypes.
    Rebecca J. Sardell, Jessica N. Cooke Bailey, Monique D. Courtenay, Patrice L. Whitehead, Reneé A. Laux, Larry Deon Adams, Jorge A. Fortun, Milam A. Brantley, Jaclyn Lekse Kovach, Stephen G. Schwartz et al. · 2016 · Europe PMC (PubMed Central)
  14. Animal Models for Eye Diseases and Therapeutics
    Takeshi Iwata, Stanislav I. Tomarev · 2008 · Humana Press eBooks
  15. The Challenges and Surprises of Studying the Genetics of Age-Related Macular Degeneration
    Elias I. Traboulsi · 2005 · American Journal of Ophthalmology
  16. Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention
    Michael B. Gorin, Michael J. daSilva · 2019 · Experimental Eye Research
  17. The Quest for Genes Causing Complex Traits in Ocular Medicine
    Sudha K. Iyengar · 2007 · Archives of Ophthalmology
  18. Genome‐Wide Scan for Loci Influencing Quantitative Immune Response Traits in the Belém Family Study: Comparison of Methods and Summary of Results
    Eleanor Wheeler, E. Nancy Miller, Christopher S. Peacock, Ian J. Donaldson, Marie‐Anne Shaw, Scott Jamieson, Jenefer Mary Blackwell, Heather Jane Cordell · 2005 · Annals of Human Genetics
  19. Intraocular calcidiol: Uncovering a role for vitamin D in the eye
    Jacob Rullo, Tracie Pennimpede, Parsa Mehraban Far, Yi Ning J. Strube, Isabella Irrcher, Todd E. Urton, Mark D. Bona, Tom Gonder, Chaim M. Bell, Martin ten Hove et al. · 2019 · The Journal of Steroid Biochemistry and Molecular Biology
  20. Age-Related Macular Degeneration
    Govindasamy Kumaramanickavel · 2016 · Asia-Pacific Journal of Ophthalmology
  21. Skin Color in Fish and Humans: Impacts on Science and Society
    Keith C. Cheng · 2008 · Zebrafish
  22. Genetics of Age-Related Macular Degeneration: Update
    Hendrik P. N. Scholl, Monika Fleckenstein, Peter Charbel Issa, Claudia N. Keilhauer, Frank Gerhard Holz, Bernhard H. F. Weber · 2007 · Essentials in ophthalmology/Essentials ophthalmology
  23. Evaluation of Retinal Structure in Pediatric Subjects With Vitamin D Deficiency
    Emre Aydemır, Çağrı İlhan, Gözde Aksoy Aydemir, Alper Halil Bayat, Semih Bolu, Abdulvahit Aşık · 2021 · American Journal of Ophthalmology
  24. Dissection of Chromosome 16p12 Linkage Peak Suggests a Possible Role for CACNG3 Variants in Age-Related Macular Degeneration Susceptibility
    Kylee L. Spencer, Lana M. Olson, Nathalie C. Schnetz‐Boutaud, Paul J. Gallins, Gaofeng Wang, William K. Scott, Anita Agarwal, Jóhanna Jakobsdóttir, Yvette P. Conley, Daniel E. Weeks et al. · 2010 · Investigative Ophthalmology & Visual Science
  25. Association of LOC387715/ARMS2 (rs10490924) Gene Polymorphism with Age-Related Macular Degeneration in the Brazilian Population
    Fábio Endo Hirata, José Paulo Cabral de Vasconcellos, Flávio MacCord Medina, Priscila Hae Hyun Rim, Enzo Augusto Medeiros Fulco, Mônica Barbosa de Melo · 2013 · Ophthalmic Genetics
  26. Human Complement Factor H and Factor H-Like Protein 1 Are Expressed in Human Retinal Pigment Epithelial Cells
    Andreas W. A. Weinberger, Cordula Eddahabi, Dörthe Carstesen, Peter F. Zipfel, Peter Walter, Christine Skerka · 2013 · Ophthalmic Research
  27. Impact of AREDS in a Developing Country 5 Years after Publication of the Study
    Daoud Fahed, Nicola G. Ghazi, Nabil M. Jabbour, Charbel D. Fahed, John C. Fahed, Haytham I. Salti · 2010 · European Journal of Ophthalmology
  28. Epidemiology of AMD
    L. Ho, Redmer van Leeuwen, Paulus T.V.M. de Jong, Johannes R. Vingerling, Caroline C. W. Klaver · 2012 · Springer eBooks
  29. Genetic and molecular biomarkers for geographic atrophy
    Bridget M. Riley-Gillis, Hannah Huh, Jie Shen, Anneke I. den Hollander · 2023 · Acta Ophthalmologica
  30. Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods
    Christopher J. Oldmeadow, Carlos Riveros, Elizabeth G. Holliday, Rodney J. Scott, Pablo Moscato, Jie Jin Wang, Paul Mitchell, Gabriëlle H.S. Buitendijk, Johannes R. Vingerling, Caroline C. W. Klaver et al. · 2011 · Genetic Epidemiology
  31. The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis
    Kevin Walters · 2005 · Journal of Human Genetics
  32. Genetics of Age-Related Macular Degeneration
    Daniel T. Kasuga, Yuhong Chen, Kang Zhang · 2011 · Springer eBooks
  33. CFH (rs1061170, rs1410996), KDR (rs2071559, rs1870377) and KDR and CFH Serum Levels in AMD Development and Treatment Efficacy
    Džastina Čebatorienė, Alvita Vilkevičiūtė, Greta Gedvilaitė, Akvile Bruzaite, Loresa Kriaučiūnienė, Dalia Žaliūnienė, Rasa Liutkevičienė · 2024 · Biomedicines
  34. HMCN1 variants aggravate epidermolysis bullosa simplex phenotype
    Shir Bergson, Ofer Sarig, Moshe Giladi, Janan Mohamad, Mariana Salem, Karina Smorodinsky-Atias, Ofir Sade, Bar Manori, Sari Assaf, Kiril Malovitski et al. · 2025 · The Journal of Experimental Medicine
  35. The time pattern of bilateral exudative age‐related macular degeneration
    Guðný Stella Guðnadóttir, Kristinn Pétur Magnússon, Einar Stefánsson, Friðbert Jónasson, Gudrun P. Helgadottir, Hákon Hrafn Sigurðsson · 2005 · Acta Ophthalmologica Scandinavica
  36. Influencia de haplotipos de polimorfismos de CFH, HTRA1 y ARMS2 en la aparición de degeneración macular asociada a la edad
    Fernando Cruz-González, R. Lorenzo-Pérez, Cristina Cañete-Campos, Emiliano Hernández-Galilea, Rogelio González‐Sarmiento · 2012 · Archivos de la Sociedad Española de Oftalmología
  37. The Impact of ARMS2 (rs10490924), VEGFA (rs3024997), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), and IL1B1 (rs1143623) Polymorphisms and Serum Levels on Age-Related Macular Degeneration Development and Therapeutic Responses
    Džastina Čebatorienė, Alvita Vilkevičiūtė, Greta Gedvilaitė, Monika Duseikaitė, Akvile Bruzaite, Loresa Kriaučiūnienė, Dalia Žaliūnienė, Rasa Liutkevičienė · 2024 · International Journal of Molecular Sciences
  38. The Chromosome 10q26 Susceptibility Locus in Age-Related Macular Degeneration
    Chloë M. Stanton, Kevin J. Chalmers, Alan F. Wright · 2011 · Advances in experimental medicine and biology
  39. Epigenetic Alterations in Age-Related Macular Degeneration: Mechanisms and Implications
    Dana Kisswani, Christina Carroll, Fátima Valdés‐Mora, Matt Rutar · 2025 · International Journal of Molecular Sciences
  40. Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease
    Fernando Cruz-González, R. Lorenzo-Pérez, Cristina Cañete-Campos, Emiliano Hernández-Galilea, Rogelio González‐Sarmiento · 2013 · Archivos de la Sociedad Española de Oftalmología (English Edition)
  41. Génétique de la dégénérescence maculaire liée à l’âge
    Eric H. Souied, Nicolas Leveziel, Josseline Kaplan, Gisèle Soubrane · 2007 · Journal Français d Ophtalmologie
  42. Genetics of Age-Related Macular Degeneration
    Rylee A. Zavala, Patrice M. Hicks, John H. Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen, Margaret M. DeAngelis · 2022 · Springer eBooks
  43. The Role of Inflammation in Age-Related Macular Degeneration
    James M. Harris, David M. Wu · 2025 · International Ophthalmology Clinics
  44. Difficult Path to Treating Acute Ischemic Stroke Patients with Transcranial Near-Infrared Laser Therapy
    Paul A. Lapchak, Pramod V. Butte, Padmesh S. Rajput · 2016
  45. Complement Activation of Drusen in Primate Model (Macaca fascicularis) for Age-Related Macular Degeneration
    Takeshi Iwata · 2007 · Springer eBooks
  46. Genetics of Age-Related Maculopathy
    O F Fafowora, Michael B. Gorin · 2012 · Oxford University Press eBooks
  47. Paradigm of Susceptibility Genes in AMD and PCV
    Moeen Riaz, Paul Nigel Baird · 2017 · Essentials in ophthalmology/Essentials ophthalmology
  48. The Coming of Age for Age-Related Macular Degeneration Genetics
    Michael B. Gorin · 2005 · Ophthalmic Genetics
  49. Epidemiologie der AMD
    Lintje Ho, Redmer van Leeuwen, Paulus T.V.M. de Jong, Johannes R. Vingerling, Caroline C. W. Klaver · 2011 · Springer eBooks
  50. Epidemiology of Age-Related Macular Degeneration Early in the 21st Century
    Jie Jin Wang, Paul Mitchell, Ronald Klein · 2007 · Humana Press eBooks
  51. Genetics of age-related macular degeneration
    Weiye Li · 2021 · Elsevier eBooks
  52. The Genetics of Common, Complex Diseases
    Jessica N. Cooke Bailey, Lucia Sobrin, Janey L. Wiggs · 2021 · Springer eBooks
  53. The Genetics of Common, Complex Diseases
    Jessica N. Cooke Bailey, Lucia Sobrin, Janey L. Wiggs · 2022 · Springer eBooks
  54. Expression of recombinant protein encoded by LOC387715 in Escherichia coli
    Dequan Chen, Marlyn P. Langford, Chris Duggan, Benjamin J. Madden, Albert O. Edwards · 2007 · Protein Expression and Purification
  55. Genetic markers for age-related macular degeneration
    Chee Wai Wong, Ching‐Yu Cheng · 2014
  56. Genetics of age-related maculopathy & Score statistics for X-linked quantitative trait loci
    Jóhanna Jakobsdóttir · 2009 · D-Scholarship@Pitt (University of Pittsburgh)
  57. Genetic Epidemiology of Age-Related Macular Degeneration (AMD): The Role of the Complement Component 2 (C2) and Complement Factor B (CFB) Genes in Determining AMD Subphenotypes
    Brooke A. C. Longville · 2009 · Murdoch University Research Portal
  58. The Application of Pooled DNA Sequencing in Disease Association Study
    Chang‐Yun Lin, Tao Wang · 2012 · InTech eBooks
  59. Biomarkers for Age-Related Macular Degeneration
    Jiayin Gu · 2009 · OhioLink ETD Center (Ohio Library and Information Network)
  60. A potential therapeutic target in age-related macular degeneration
    A Churchill, James G. Carter · 2007 · Therapy
  61. Genetic and modifiable risk factors for age-related macular degeneration
    Jie Jin Wang · 2006 · Expert Review of Ophthalmology
  62. Genetics of Ocular Vascular Disease
    Jacquie Greenberg, Ari Ziskind, Stephen P. Daiger · 2007 · Humana Press eBooks
  63. Epidemiology and Aetiopathogenesis of Age-Related Macular Degeneration
    John T. Landrum, John Nolan · 2013 · CRC Press eBooks
  64. Variants in complement factor pathway genes and a novel locus on chromosome 16p12 influence age-related macular degeneration susceptibility
    Kylee L. Spencer · 2007 · Europe PMC (PubMed Central)
  65. Chapter 43 Photobiomodulation for the Clinical Treatment of Age-Related Macular Degeneration
    Graham Merry, Robert S. Dotson · 2016 · Pan Stanford Publishing Pte. Ltd. eBooks
  66. Mitochondrial DNA (mtDNA) Variant-Nuclear DNA Variant Interactions and Gene-Dietary Exposure Interactions in Age-Related Macular Degeneration (AMD)
    Patrice J. Persad · 2017
  67. Molecular Genetics of Macular Degeneration
    Jessica N. Cooke Bailey, Jonathan L. Haines · 2016 · Wiley eBooks
  68. Segregation, linkage, GWAS, and sequencing
    Andrea R. Waksmunski, Leighanne R. Main, Jonathan L. Haines · 2019 · Elsevier eBooks
  69. Genetics in Age-Related Macular Degeneration
    Giridhar Anantharaman, Aarti Jain · 2022 · Springer eBooks
  70. Genetics of Age-Related Macular Degeneration
    Rylee A. Zavala, Patrice M. Hicks, John H. Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen, Margaret M. DeAngelis · 2021 · Springer eBooks
  71. Degeneration
    2010 · Elsevier eBooks
  72. Epidemiology and Aetiopathogenesis of Age-Related Macular Degeneration
    Sobha Sivaprasad, Phil Hykin · 2013 · CRC Press eBooks
  73. Age-Related Macular Degeneration and Primary Open-Angle Glaucoma: Genetics and Gene-Environment Interaction
    Gabriëlle H.S. Buitendijk, Henriët Springelkamp, Lintje Ho, Caroline C. W. Klaver · 2013 · Essentials in ophthalmology/Essentials ophthalmology