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Progress toward Characterization of the Group A Streptococcus Metagenome: Complete Genome Sequence of a Macrolide‐Resistant Serotype M6 Strain
Abstract
We describe the genome sequence of a macrolide-resistant strain (MGAS10394) of serotype M6 group A Streptococcus (GAS). The genome is 1,900,156 bp in length, and 8 prophage-like elements or remnants compose 12.4% of the chromosome. A 8.3-kb prophage remnant encodes the SpeA4 variant of streptococcal pyrogenic exotoxin A. The genome of strain MGAS10394 contains a chimeric genetic element composed of prophage genes and a transposon encoding the mefA gene conferring macrolide resistance. This chimeric element also has a gene encoding a novel surface-exposed protein (designated "R6 protein"), with an LPKTG cell-anchor motif located at the carboxyterminus. Surface expression of this protein was confirmed by flow cytometry. Humans with GAS pharyngitis caused by serotype M6 strains had antibody against the R6 protein present in convalescent, but not acute, serum samples. Our studies add to the theme that GAS prophage-encoded extracellular proteins contribute to host-pathogen interactions in a strain-specific fashion.
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Cites
Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Achtman, M., Zurth, K., Morelli, G., Torrea, G., Guiyoule, A., & Carniel, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14043 · Cited by 1,126
Cited by
Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus
Walker, M. J., Barnett, T. C., McArthur, J. D., Cole, J. N., Gillen, C. M., Henningham, A., Sriprakash, K. S., Sanderson-Smith, M. L., & Nizet, V. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00101-13 · Cited by 908
Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Environmental Samples
Colomer-Lluch, M., Jofre, J., & Muniesa, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017549 · Cited by 353
Metadata
- Authors
- Banks, D. J., Porcella, S. F., Barbian, K. D., Beres, S. B., Philips, L. E., Voyich, J. M., DeLeo, F. R., Martin, J. M., Somerville, G. A., & Musser, J. M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-15
- Volume
- 190
- Issue
- 4
- Pages
- 727-738
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2004280494
- Cited by
- 177
- References
- 1
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Banks, D. J., Porcella, S. F., Barbian, K. D., Beres, S. B., Philips, L. E., Voyich, J. M., DeLeo, F. R., Martin, J. M., Somerville, G. A., & Musser, J. M. (2004). Progress toward Characterization of the Group A Streptococcus Metagenome: Complete Genome Sequence of a Macrolide‐Resistant Serotype M6 Strain. The Journal of Infectious Diseases. https://doi.org/10.1086/422697
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
