Cited by 44Probiotics and Fermented FoodsReproductive tract infections researchNeonatal and Maternal Infections

Phenotypic differences between commercial Lactobacillus rhamnosus GG and L. rhamnosus strains recovered from blood

Ouwehand, A. C., Saxelins, M., Salminen, S.·2004·Clinical Infectious Diseases

Abstract

The isolation of clinical isolates that are indistinguishable, by molecular methods, from the probiotic strain of Lactobacillus rhamnosus GG has been reported. We compared the virulence potential of these clinical isolates with that of the probiotic strain. It was observed that all isolates differed significantly in 1 or more phenotypic properties.

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  • LB may be underdiagnosed, as lactobacilli are difficult to culture and identify, and in many cases have been deemed as contaminants in blood samples.

    “LB may be underdiagnosed, as lactobacilli are difficult to culture and identify, and, in many cases, have been deemed as contaminants in blood samples [2,21].”

    From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [21]

    The Materials and methods section (page unavailable) describes culturing blood isolates and identifying them by PCR and PFGE, but does not say that lactobacilli are difficult to culture or identify. The Discussion (page unavailable) reports a low incidence of Lactobacillus bacteremia; neither it nor the passages retrieved for underdiagnosis and blood-sample contaminants says that cases are underdiagnosed or that isolates are commonly dismissed as contaminants. (LLM, conf=0.76)

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References 11 · Cited by 44

Research works printed but not linked: 2

  1. Ouwehand AC, Tuomola EM, Lee YK, Salminen S. Microbial inter- actions to intestinal mucosal models. Meth Enzymol 2001; 337:200-12.
  2. Asahara T, Takahashi M, Nomoto K, et al. Assessment of safety of Lactobacillus strains based on resistance to host innate defence mech- anisms. Clin Diag Lab Immunol 2003; 10:169-73.

Authors
Ouwehand, A. C., Saxelins, M., & Salminen, S.
Affiliations
  • University of Turku (FI)
  • Valio (Finland) (FI)
Corresponding author
Ouwehand, A. C.
Venue
Clinical Infectious Diseases
Published
2004-12-15
Volume
39
Issue
12
Pages
1858-1860
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2098706584
Cited by
44
References
11
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
Valio
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
Lactobacillus rhamnosus GG, probiotics, clinical isolates, virulence, phenotypic differences, blood culture isolates
MeSH terms
Humans, Lactobacillus, Phenotype, Plasma, Virulence, Bacteremia, Probiotics

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