The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immunogenicity and Reactogenicity of 1 versus 2 Doses of Trivalent Inactivated Influenza Vaccine in Vaccine‐Naive 5–8‐Year‐Old Children
Open accessAbstract
BACKGROUND: Two doses of trivalent inactivated influenza vaccine (TIV) are recommended for children <9 years old receiving vaccine for the first time, but compliance is suboptimal. This study assessed the need for a second dose of TIV in this age group. METHODS: In this prospective, open-label study, 232 influenza vaccine-naive 5-8-year-olds enrolled in a health maintenance organization received 2 doses of TIV in fall 2004. Serum for antibody titer measurement was obtained at 3 time points (n = 222). Parents completed diaries for 5 days. RESULTS: Both doses of vaccine were well tolerated. The strongest predictor of a protective antibody response (> or =1 : 40) after 1 dose of TIV was baseline seropositive status. In multivariate analysis adjusting for age, sex, and baseline serostatus, the proportion of children with protective antibody responses was significantly higher after 2 doses than after 1 dose of TIV for each antigen (P < .001, for A/H1N1; P = .01, for A/H3N2; P < .001, for B). Age and sex were not independently predictive of a protective antibody response. Over one-third of children had antibody responses <1:40 for the type B vaccine component, even after 2 doses. CONCLUSIONS: The present study supports the need for 2 doses of TIV in 5-8-year-olds receiving TIV for the first time. Efforts to increase compliance with the 2-dose recommendation are warranted.
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Belshe, R. B., Mendelman, P. M., Treanor, J., King, J., Gruber, W. C., Piedra, P., Bernstein, D. I., Hayden, F. G., Kotloff, K., Zangwill, K., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382002 · Cited by 916
Cited by
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,632
(2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03793.x · Cited by 957
The evolution of seasonal influenza viruses
Petrova, V. N., & Russell, C. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.118 · Cited by 846
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. S. (2016) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 593
Vaccines for preventing influenza in healthy children
Jefferson, T., Rivetti, A., Di Pietrantonj, C., Demicheli, V., & Ferroni, E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004879.pub4 · Cited by 553
Metadata
- Authors
- Neuzil, K. M., Jackson, L. A., Nelson, J., Klimov, A., Cox, N., Bridges, C. B., Dunn, J., DeStefano, F., & Shay, D.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-15
- Volume
- 194
- Issue
- 8
- Pages
- 1032-1039
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2151926553
- Cited by
- 191
- References
- 1
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Neuzil, K. M., Jackson, L. A., Nelson, J., Klimov, A., Cox, N., Bridges, C. B., Dunn, J., DeStefano, F., & Shay, D. (2006). Immunogenicity and Reactogenicity of 1 versus 2 Doses of Trivalent Inactivated Influenza Vaccine in Vaccine‐Naive 5–8‐Year‐Old Children. The Journal of Infectious Diseases. https://doi.org/10.1086/507309
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