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Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis
Open accessAbstract
We measured the plasma procalcitonin levels in 59 children who were admitted to the hospital because of bacterial or viral meningitis. Eighteen children with acute bacterial meningitis had elevated procalcitonin levels (mean level, 54.5 micrograms/L; range, 4.8-110 micrograms/L). The procalcitonin levels in 41 children with viral meningitis were low (mean level, 0.32 micrograms/L; range, 0-1.7 micrograms/L; P < .0001). Assay of cerebrospinal fluid (CSF) cells and proteins and serum C-reactive protein showed a zone of overlapping values between the two groups. Procalcitonin was not produced in CSF. Plasma procalcitonin levels decreased rapidly during antibiotic therapy. These data suggest that the measurement of plasma procalcitonin might be of value in the differential diagnosis of meningitis due to either bacteria or viruses.
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Cited by
Practice Guidelines for the Management of Bacterial Meningitis
Tunkel, A. R., Hartman, B. J., Kaplan, S. L., Kaufman, B. A., Roos, K. L., Scheld, W. M., & Whitley, R. J. (2004) · Clinical Infectious Diseases · doi:10.1086/425368 · Cited by 2,308
Castelli, G. P., Pognani, C., Meisner, M., Stuani, A., Bellomi, D., & Sgarbi, L. (2004) · Critical Care · doi:10.1186/cc2877 · Cited by 417
Procalcitonin as an early marker of infection in neonates and children
van Rossum, A., Wulkan, R., & Oudesluys-Murphy, A. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01146-6 · Cited by 310
Cuquemelle, E., Soulis, F., Villers, D., Roche-Campo, F., Ara Somohano, C., Fartoukh, M., Kouatchet, A., Mourvillier, B., Dellamonica, J., Picard, W., et al. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2189-1 · Cited by 109
Metadata
- Authors
- Gendrel, D., Raymond, J., Assicot, M., Moulin, F., Iniguez, J., Lebon, P., & Bohuon, C.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-06
- Volume
- 24
- Issue
- 6
- Pages
- 1240-1242
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2162737218
- Cited by
- 274
- References
- 0
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gendrel, D., Raymond, J., Assicot, M., Moulin, F., Iniguez, J., Lebon, P., & Bohuon, C. (1997). Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis. Clinical Infectious Diseases. https://doi.org/10.1086/513633
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