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Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever
Open accessAbstract
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.
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Cited by
Exotic emerging viral diseases: progress and challenges
Geisbert, T. W., & Jahrling, P. B. (2004) · Nature Medicine · doi:10.1038/nm1142 · Cited by 441
Zoonotic aspects of arenavirus infections
Charrel, R. N., & de Lamballerie, X. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.08.027 · Cited by 162
Pigott, D. C. (2005) · Critical Care Clinics · doi:10.1016/j.ccc.2005.06.007 · Cited by 61
Metadata
- Authors
- Maiztegui, J. I., McKee, Jr., Oro, J. G. B., Harrison, L. H., Gibbs, P. H., Feuillade, M. R., Enria, D. A., Briggiler, A. M., Levis, S. C., Ambrosio, A. M., Halsey, N. A., Peters, C. J., & the AHF Study Group
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-02
- Volume
- 177
- Issue
- 2
- Pages
- 277-283
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2148440555
- Cited by
- 263
- References
- 0
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever. https://app.cochat.ai/papers/10.1086/514211
- The paper
- Maiztegui, J. I., McKee, Jr., Oro, J. G. B., Harrison, L. H., Gibbs, P. H., Feuillade, M. R., Enria, D. A., Briggiler, A. M., Levis, S. C., Ambrosio, A. M., Halsey, N. A., Peters, C. J., & the AHF Study Group. (1998). Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever. The Journal of Infectious Diseases. https://doi.org/10.1086/514211
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
