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Ebola Hemorrhagic Fever in Kikwit, Democratic Republic of the Congo: Clinical Observations in 103 Patients
Open accessAbstract
During the 1995 outbreak of Ebola hemorrhagic fever in the Democratic Republic of the Congo, a series of 103 cases (one-third of the total number of cases) had clinical symptoms and signs accurately recorded by medical workers, mainly in the setting of the urban hospital in Kikwit. Clinical diagnosis was confirmed retrospectively in cases for which serum samples were available (n = 63, 61% of the cases). The disease began unspecifically with fever, asthenia, diarrhea, headaches, myalgia, arthralgia, vomiting, and abdominal pain. Early inconsistent signs and symptoms included conjunctival injection, sore throat, and rash. Overall, bleeding signs were observed in <45% of the cases. Typically, terminally ill patients presented with obtundation, anuria, shock, tachypnea, and normothermia. Late manifestations, most frequently arthralgia and ocular diseases, occurred in convalescent patients. This series is the most extensive number of cases of Ebola hemorrhagic fever observed during an outbreak.
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Cited by
Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., Carter, A., Casey, D. C., Charlson, F. J., Chen, A. Z., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31678-6 · Cited by 7,253
Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections
WHO Ebola Response Team (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1411100 · Cited by 1,674
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Geisbert, T. W., & Jahrling, P. B. (2004) · Nature Medicine · doi:10.1038/nm1142 · Cited by 441
Late Ebola virus relapse causing meningoencephalitis: a case report
Jacobs, M., Rodger, A., Bell, D. J., Bhagani, S., Cropley, I., Filipe, A., Gifford, R. J., Hopkins, S., Hughes, J., Jabeen, F., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30386-5 · Cited by 361
Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus
Bausch, D. G., Nichol, S. T., Muyembe-Tamfum, J. J., Borchert, M., Rollin, P. E., Sleurs, H., Campbell, P., Tshioko, F. K., Roth, C., Colebunders, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051465 · Cited by 307
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Metadata
- Authors
- Bwaka, M. A., Bonnet, M., Calain, P., Colebunders, R., De Roo, A., Guimard, Y., Katwiki, K. R., Kibadi, K., Kipasa, M. A., Kuvula, K. J., Mapanda, B. B., Massamba, M., Mupapa, K. D., Muyembe‐Tamfum, J., Ndaberey, E., Peters, C. J., Rollin, P. E., & Van den Enden, E.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 179
- Issue
- s1
- Pages
- S1-S7
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2163760194
- Cited by
- 465
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bwaka, M. A., Bonnet, M., Calain, P., Colebunders, R., De Roo, A., Guimard, Y., Katwiki, K. R., Kibadi, K., Kipasa, M. A., Kuvula, K. J., Mapanda, B. B., Massamba, M., Mupapa, K. D., Muyembe‐Tamfum, J., Ndaberey, E., Peters, C. J., Rollin, P. E., & Van den Enden, E. (1999). Ebola Hemorrhagic Fever in Kikwit, Democratic Republic of the Congo: Clinical Observations in 103 Patients. The Journal of Infectious Diseases. https://doi.org/10.1086/514308
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