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Counterpoint: Vancomycin and Staphylococcus aureus--An Antibiotic Enters Obsolescence
Abstract
The efficacy of vancomycin for the treatment of patients with infections due to Staphylococcus aureus is impaired by its poor tissue penetration and by its relatively weak antibacterial activity--an activity that is declining as S. aureus evolves. Neither dose escalation nor use of vancomycin in combination with other antibiotics that have antistaphylcoccal activity has been demonstrated to safely enhance its therapeutic efficacy. Although no clinical trials suggest superiority of vancomycin over any comparator, some have provided evidence of its inferiority. Strong consideration should be given to the use of alternative agents in the treatment of serious S. aureus infections.
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Citations
Cited by
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Rybak, M., Lomaestro, B., Rotschafer, J. C., Moellering, R., Craig, W., Billeter, M., Dalovisio, J. R., & Levine, D. P. (2009) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp080434 · Cited by 1,795
Role of Folate Antagonists in the Treatment of Methicillin-Resistant Staphylococcus aureus Infection
Goldstein, E. J. C., & Proctor, R. A. (2008) · Clinical Infectious Diseases · doi:10.1086/525536 · Cited by 138
Carugati, M., Bayer, A. S., Miró, J. M., Park, L. P., Guimarães, A. C., Skoutelis, A., Fortes, C. Q., Durante-Mangoni, E., Hannan, M. M., Nacinovich, F., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01563-13 · Cited by 100
Metadata
- Authors
- Deresinski, S.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-15
- Volume
- 44
- Issue
- 12
- Pages
- 1543-1548
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2140764008
- Cited by
- 173
- References
- 0
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
